Successful post-incomplete resection management of gastrointestinal stromal tumor using imatinib based on adenosine triphosphate-based tumor sensitivity assay in a dog.

In-Sun Woo, Young-Rok Kim, Sang-Won Kim, Jin-Young Choi, Hun-Young Yoon, Kieun Bae, Kyong-Ah Yoon, Jung-Hyun Kim

Abstract readCase Reports

In one paragraph

Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

In-Sun WooKU Animal Cancer Center, Konkuk University Veterinary Medical Teaching Hospital, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea (Woo, Y-R Kim, S-W Kim, Choi, H-Y Yoon, Bae, K-A Yoon, J-H Kim); Department of Veterinary Internal Medicine (Woo, Y-R Kim, S-W Kim, J-H Kim) and Department of Veterinary Surgery (Choi, H-Y Yoon) and Department of Veterinary Biochemistry (Bae, K-A Yoon), College of Veterinary Medicine, Konkuk University, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.

Young-Rok KimKU Animal Cancer Center, Konkuk University Veterinary Medical Teaching Hospital, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea (Woo, Y-R Kim, S-W Kim, Choi, H-Y Yoon, Bae, K-A Yoon, J-H Kim); Department of Veterinary Internal Medicine (Woo, Y-R Kim, S-W Kim, J-H Kim) and Department of Veterinary Surgery (Choi, H-Y Yoon) and Department of Veterinary Biochemistry (Bae, K-A Yoon), College of Veterinary Medicine, Konkuk University, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.

Sang-Won KimKU Animal Cancer Center, Konkuk University Veterinary Medical Teaching Hospital, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea (Woo, Y-R Kim, S-W Kim, Choi, H-Y Yoon, Bae, K-A Yoon, J-H Kim); Department of Veterinary Internal Medicine (Woo, Y-R Kim, S-W Kim, J-H Kim) and Department of Veterinary Surgery (Choi, H-Y Yoon) and Department of Veterinary Biochemistry (Bae, K-A Yoon), College of Veterinary Medicine, Konkuk University, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.

Jin-Young ChoiKU Animal Cancer Center, Konkuk University Veterinary Medical Teaching Hospital, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea (Woo, Y-R Kim, S-W Kim, Choi, H-Y Yoon, Bae, K-A Yoon, J-H Kim); Department of Veterinary Internal Medicine (Woo, Y-R Kim, S-W Kim, J-H Kim) and Department of Veterinary Surgery (Choi, H-Y Yoon) and Department of Veterinary Biochemistry (Bae, K-A Yoon), College of Veterinary Medicine, Konkuk University, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.

Hun-Young YoonKU Animal Cancer Center, Konkuk University Veterinary Medical Teaching Hospital, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea (Woo, Y-R Kim, S-W Kim, Choi, H-Y Yoon, Bae, K-A Yoon, J-H Kim); Department of Veterinary Internal Medicine (Woo, Y-R Kim, S-W Kim, J-H Kim) and Department of Veterinary Surgery (Choi, H-Y Yoon) and Department of Veterinary Biochemistry (Bae, K-A Yoon), College of Veterinary Medicine, Konkuk University, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.

Kieun BaeKU Animal Cancer Center, Konkuk University Veterinary Medical Teaching Hospital, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea (Woo, Y-R Kim, S-W Kim, Choi, H-Y Yoon, Bae, K-A Yoon, J-H Kim); Department of Veterinary Internal Medicine (Woo, Y-R Kim, S-W Kim, J-H Kim) and Department of Veterinary Surgery (Choi, H-Y Yoon) and Department of Veterinary Biochemistry (Bae, K-A Yoon), College of Veterinary Medicine, Konkuk University, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.

Kyong-Ah YoonKU Animal Cancer Center, Konkuk University Veterinary Medical Teaching Hospital, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea (Woo, Y-R Kim, S-W Kim, Choi, H-Y Yoon, Bae, K-A Yoon, J-H Kim); Department of Veterinary Internal Medicine (Woo, Y-R Kim, S-W Kim, J-H Kim) and Department of Veterinary Surgery (Choi, H-Y Yoon) and Department of Veterinary Biochemistry (Bae, K-A Yoon), College of Veterinary Medicine, Konkuk University, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.

Jung-Hyun KimKU Animal Cancer Center, Konkuk University Veterinary Medical Teaching Hospital, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea (Woo, Y-R Kim, S-W Kim, Choi, H-Y Yoon, Bae, K-A Yoon, J-H Kim); Department of Veterinary Internal Medicine (Woo, Y-R Kim, S-W Kim, J-H Kim) and Department of Veterinary Surgery (Choi, H-Y Yoon) and Department of Veterinary Biochemistry (Bae, K-A Yoon), College of Veterinary Medicine, Konkuk University, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrointestinal stromal tumors arising from gastric cardia are uncommon in dogs. A few studies have shown the effectiveness of tyrosine kinase inhibitors in the treatment of canine gastrointestinal stromal tumors, but no standardized protocols are currently available. An 11-year-old spayed female Maltese dog was diagnosed with a gastrointestinal stromal tumor using histopathological and immunohistochemical analyses. An adenosine triphosphate-based tumor chemosensitivity assay revealed that imatinib at lower concentrations had a stronger inhibitory effect than toceranib. Based on the results of the assay, the dog was treated with imatinib after surgery. After 28 mo of therapy, there was no recurrence of the tumor. Key clinical message: Adenosine triphosphate-based tumor chemosensitivity assays may help clinicians to select appropriate postoperative chemotherapeutic drugs for incompletely resected gastrointestinal stromal tumors in dogs.

Indexed as

Antineoplastic AgentsDog DiseasesGastrointestinal Stromal TumorsImatinib MesylateAdenosine TriphosphateAnimalsDogsFemaleIndolesPyrrolesAdenosine TriphosphateAntineoplastic AgentsImatinib MesylateIndolesPyrrolestoceranib phosphate

Identifiers

PMID38827592

PMCPMC11132173

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.