Evidence map›Paper›PMID 38827574›Full record

ArticleFrontiers in neurology2024

Relationship between Contingent Negative Variation and afterimage duration in migraine patients.

Simeon Giesen, Florian Rimmele, Tim P Jürgens, Jörg Scheidt, Johannes Drescher, Ann-Kristin Leonhardt, Sophia Schulze, Birgit Harbeck, Wolfgang Meyer, Britta Müller and 2 more

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Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Simeon GiesenInstitute of Medical Psychology and Medical Sociology, University of Rostock Medical Center, Rostock, Germany.
Florian RimmeleDepartment of Neurology, University of Rostock Medical Center, Rostock, Germany.
Tim P JürgensDepartment of Neurology, University of Rostock Medical Center, Rostock, Germany.
Jörg ScheidtInstitute for Informations Systems, University of Applied Sciences, Hof, Germany.
Johannes DrescherInstitute for Informations Systems, University of Applied Sciences, Hof, Germany.
Ann-Kristin LeonhardtInstitute of Medical Psychology and Medical Sociology, University of Rostock Medical Center, Rostock, Germany.
Sophia SchulzeInstitute of Medical Psychology and Medical Sociology, University of Rostock Medical Center, Rostock, Germany.
Birgit HarbeckIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Wolfgang MeyerInstitute of Medical Psychology and Medical Sociology, University of Rostock Medical Center, Rostock, Germany.
Britta MüllerInstitute of Medical Psychology and Medical Sociology, University of Rostock Medical Center, Rostock, Germany.
Peter KroppInstitute of Medical Psychology and Medical Sociology, University of Rostock Medical Center, Rostock, Germany.
Armin KellerInstitute of Medical Psychology and Medical Sociology, University of Rostock Medical Center, Rostock, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Abnormalities in electrocortical parameters and persistence of afterimage after visual stimulation are known to occur in migraine patients. The results of studies on Contingent Negative Variation (CNV) and afterimage persistence in migraine patients suggest a link between these two phenomena and a connection to the pathomechanism of migraine. Objectives: To date, no studies have investigated both afterimage duration and CNV parameters in the same subjects. The aim of this study was to investigate the relationship between the early component of CNV (iCNV) and the duration of the afterimage in migraine patients. Methods: Sixty seven migraine patients from the headache center of the University of Rostock Medical Center were examined for iCNV amplitude, iCNV habituation and afterimage duration. The subjects also completed questionnaires developed for this study and the MIDAS (Migraine Disability Assessment) questionnaire. Results: Associations were found between iCNV amplitude and afterimage duration and between habituation capacity and afterimage duration. A deficit in habituation capacity correlated with a significantly prolonged afterimage duration. Increased iCNV amplitude and prolonged afterimage duration were also significantly correlated. Conclusion: Conclusions about the pathophysiology of migraine can be drawn from the results of this study. The results support the hypothesis of cortical hyperexcitability as a consequence of a low pre-activation level, which may be a possible contributory cause of migraine. Furthermore, they allow assessment of whether the afterimage examination, which is easier and quicker to perform than the CNV examination, can be used as a diagnostic tool or as a parameter to monitor the course of therapy in people with migraine.

Indexed as

after imageContingent Negative Variationfuture migraine therapymigrainepathomechanismpreemptive therapy

Identifiers

PMID38827574
PMCPMC11141693

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