Evidence map›Paper›PMID 38827400›Full record

ArticleiScience2024

Defining cis-regulatory elements and transcription factors that control human cortical interneuron development.

Gareth Chapman, Julianna Determan, Haley Jetter, Komal Kaushik, Ramachandran Prakasam, Kristen L Kroll

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. International journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gareth ChapmanDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Julianna DetermanDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Haley JetterDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Komal KaushikDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ramachandran PrakasamDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kristen L KrollDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
Genomic and functional characterization of ASD and ID-associated MYT1L mutationR01MH124808 · NIMH · WASHINGTON UNIVERSITY · PI KROLL, KRISTEN L · 2021 to 2025
$3.7M
Multi-organism platform for functional assessment of human birth defect associated genomic variantsR01HD110556 · NICHD · WASHINGTON UNIVERSITY · PI AARON N JOHNSON, Kristen L Kroll · 2023 to 2026
$2.5M
The cis-regulatory grammar and epigenetic control of human interneuron progenitor specificationR01NS114551 · NINDS · WASHINGTON UNIVERSITY · PI KROLL, KRISTEN L · 2021 to 2024
$2.1M
NCATS NIH HHS UL1 TR002345NICHD NIH HHS P50 HD103525NICHD NIH HHS R01 HD110556NIMH NIH HHS R01 MH124808NINDS NIH HHS R01 NS114551
6 · The paper itself

Abstract

Although human cortical interneurons (cINs) are a minority population in the cerebral cortex, disruption of interneuron development is a frequent contributor to neurodevelopmental disorders. Here, we utilized a model for deriving cINs from human embryonic stem cells to profile chromatin state changes and generate an atlas of

Indexed as

Biological sciencesDevelopmental neuroscienceEpigeneticsNeuroscience

Identifiers

PMID38827400
PMCPMC11140214

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.