ArticleIranian journal of biotechnology2024
Recombinant Expression and Functional Assessment of Uricase from a Pertinent Origin of the Enzyme,
Article in Iranian journal of biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Pharmaceutical applications of halophilic enzymes.Heliyon · 2025Review
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Authors and funding
6 authors.
Funding
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Abstract
Background: Uricase or urate oxidase, as a therapeutic enzyme, is extensively applied to oxidize accumulated uric acid in the body to soluble form to treat related illnesses. Objectives: This study was conducted with the aim of searching for potential sources of uricase-producing Materials and Methods: Main screening was conducted by cultivation of the strains on a medium enriched with 0.3 percent (w/v) uric acid. The uricase gene from the most potent strain was then recombinantly expressed in Results: Out of the tested strains, only seven showed uricase activity. The highest level of native uricase activity (11.5735 U.mL Conclusions: This enzyme is a promising candidate for further applicable investigations and large-scale production in terms of its large volume of soluble expression and selective competitive activity.
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