Evidence map›Paper›PMID 38827303›Full record

ArticlePeerJ2024

Epigallocatechin gallate protects MC3T3-E1 cells from cadmium-induced apoptosis and dysfunction via modulating PI3K/AKT/mTOR and Nrf2/HO-1 pathways.

Fanhao Wei, Kai Lin, Binjia Ruan, Chaoyong Wang, Lixun Yang, Hongwei Wang, Yongxiang Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Investigating the Osteoregenerative Properties ofJournal of functional biomaterials · 2025
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fanhao Wei *Clinical Medical College, Yangzhou University, Yangzhou, China.
Kai Lin *Nanjing University Medical School, Nanjing, China.
Binjia RuanNanjing University Medical School, Nanjing, China.
Chaoyong WangNanjing University Medical School, Nanjing, China.
Lixun YangClinical Medical College, Yangzhou University, Yangzhou, China.
Hongwei WangNanjing University Medical School, Nanjing, China.
Yongxiang WangClinical Medical College, Yangzhou University, Yangzhou, China.

Funding

Jiangsu Province Traditional Chinese Medicine Technology Development Plan ProjectSecond Level Project of the “333 Project” of Jiangsu ProvinceYangzhou Municipal Key Laboratory Cultivation Project
6 · The paper itself

Abstract

Epigallocatechin gallate (EGCG), an active constituent of tea, is recognized for its anticancer and anti-inflammatory properties. However, the specific mechanism by which EGCG protects osteoblasts from cadmium-induced damage remains incompletely understood. Here, the action of EGCG was investigated by exposing MC3T3-E1 osteoblasts to EGCG and CdCl

Indexed as

ApoptosisCatechinOsteoblastsSignal TransductionAnimalsCadmiumCell DifferentiationCell LineHeme Oxygenase-1Membrane ProteinsMiceNF-E2-Related Factor 2Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesCadmiumCatechinepigallocatechin gallateHeme Oxygenase-1Hmox1 protein, mouseMembrane ProteinsmTOR protein, mouseNfe2l2 protein, mouseNF-E2-Related Factor 2Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesAKTCadmium-inducedEpigallocatechin gallateNrf2OsteoblastOxidative stress

Identifiers

PMID38827303
PMCPMC11141548

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.