Evidence map›Paper›PMID 38827219›Full record

ArticleFrontiers in pediatrics2024

Growth and gut comfort of healthy term infants exclusively fed with a partially hydrolysed protein-based infant formula: a randomized controlled double-blind trial.

Paris Kantaras, Anna Kokkinopoulou, Jeske H J Hageman, Maria Hassapidou, Odysseas Androutsos, Maria Kanaki, Ingeborg Bovee-Oudenhoven, Eva Karaglani, Aikaterini-Maria Kontochristopoulou, Rolf Bos and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05757323 (A Randomized, Controlled, Double-blind Parallel Group Trial to Study the Effects of an Infant Formula Containing Partially Hydrolysed Proteins on Growth and Tolerance in Healthy Term Infants), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05757323 nacompletednot on this map

A Randomized, Controlled, Double-blind Parallel Group Trial to Study the Effects of an Infant Formula Containing Partially Hydrolysed Proteins on Growth and Tolerance in Healthy Term Infants

TypeinterventionalSponsorFrieslandCampinaRan2021 to 2022Enrolled345ConditionsGrowthArmsinfant formula based on hydrolyzed protein, infant formula based on intact protein
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Paris KantarasDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Anna KokkinopoulouDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, Thessaloniki, Greece.
Jeske H J HagemanFrieslandCampina, Amersfoort, Netherlands.
Maria HassapidouDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, Thessaloniki, Greece.
Odysseas AndroutsosLab of Clinical Nutrition-Dietetics, Department of Nutrition and Dietetics, School of Physical Education, Sport Science and Dietetics, University of Thessaly, Trikala, Greece.
Maria KanakiLab of Clinical Nutrition-Dietetics, Department of Nutrition and Dietetics, School of Physical Education, Sport Science and Dietetics, University of Thessaly, Trikala, Greece.
Ingeborg Bovee-OudenhovenFrieslandCampina, Amersfoort, Netherlands.
Eva KaraglaniDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Aikaterini-Maria KontochristopoulouDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Rolf BosFrieslandCampina, Amersfoort, Netherlands.
Yannis ManiosDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to investigate growth and gut comfort of healthy infants fed with a partially hydrolysed cow's milk protein-based infant formula (pHF) compared to a standard intact cow's milk protein-based formula (IPF). Methods: A double-blind, multi-center, randomized, controlled trial was performed. Healthy full-term, exclusively formula-fed infants ( Results: Overall, 288 infants completed the study (pHF group: 138, IPF group: 150). No differences were observed between the two groups in weight gain (g/d) during the three-months intervention [ Conclusions: The study demonstrates that the consumption of pHF results in adequate infant growth, equivalent to that of infants consuming IPF. Furthermore, the overall gut comfort was comparable between the two groups. Therefore, it can be concluded that the pHF is safe for and well tolerated by healthy infants. Clinical Trial Registration: https://clinicaltrials.gov/study/NCT05757323?id=NCT05757323&rank=1, identifier (NCT05757323).

Indexed as

anthropometrycow's milk protein hydrolysategrowthgut comfortinfant formulapartially hydrolysed formula

Identifiers

PMID38827219
PMCPMC11141394

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.