Evidence map›Paper›PMID 38826689›Full record

ArticleFrontiers in audiology and otology2024

A cell type-specific approach to elucidate the role of miR-96 in inner ear hair cells.

Kathleen Gwilliam, Michal Sperber, Katherine Perry, Kevin P Rose, Laura Ginsberg, Nikhil Paladugu, Yang Song, Beatrice Milon, Ran Elkon, Ronna Hertzano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in audiology and otology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Correlation Analysis Between rs718447 Polymorphism of miR-204-5p and Sudden Sensorineural Hearing Loss in the Chinese Han Population.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kathleen GwilliamSection on Omics and Translational Science of Hearing, Neurotology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, United States.
Michal SperberDepartment of Human Molecular Genetics and Biochemistry, Tel Aviv University School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Katherine PerryDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, United States.
Kevin P RoseSection on Omics and Translational Science of Hearing, Neurotology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, United States.
Laura GinsbergDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, United States.
Nikhil PaladuguDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, United States.
Yang SongInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, United States.
Beatrice MilonSection on Omics and Translational Science of Hearing, Neurotology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, United States.
Ran ElkonDepartment of Human Molecular Genetics and Biochemistry, Tel Aviv University School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Ronna HertzanoSection on Omics and Translational Science of Hearing, Neurotology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, United States.

Funding

Multi-Omic and Functional Analyses for Hearing Preservation and RestorationZIADC000094 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI HERTZANO, RONNA · 2023 to 2025
$10.3M
COMPARATIVE AND EVOLUTIONARY BIOLOGY OF HEARINGT32DC000046 · NIDCD · UNIV OF MARYLAND, COLLEGE PARK · PI Catherine Emily Carr, Matthew J. Goupell · 1994 to 2026
$7.5M
Cell Type Specific Transcriptional Cascades in Inner Ear DevelopmentR01DC013817 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI HERTZANO, RONNA · 2015 to 2022
$3.6M
A Triple Line of Defense: The Role of the Group 1 RFX Transcription Factors in the Inner EarF31DC019517 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI GWILLIAM, KATHLEEN MICHELLE · 2021 to 2023
$87k
TEMPORAL ACOUSTIC ANALYSIS IN LATERAL LEMNISCAL NUCLEIF32DC000094 · NIDCD · DUKE UNIVERSITY · PI HUFFMAN, RUSSELL F · 1992 to 1995
–
Intramural NIH HHS ZIA DC000094NIDCD NIH HHS F31 DC019517NIDCD NIH HHS F32 DC000094NIDCD NIH HHS R01 DC013817NIDCD NIH HHS T32 DC000046Wellcome Trust
6 · The paper itself

Abstract

Introduction: Mutations in microRNA-96 (miR-96), a microRNA expressed within the hair cells (HCs) of the inner ear, result in progressive hearing loss in both mouse models and humans. In this study, we present the first HC-specific RNA-sequencing (RNA-seq) dataset from newborn Methods: Bulk RNA-seq was performed on HCs of newborn Results: We identify 215 upregulated and 428 downregulated genes in the HCs of the Conclusion: Our data further support a role for miR-96 in HC development, possibly as a repressor of supporting cell transcriptional programs in HCs. The HC-specific

Indexed as

diminuendohair cellinner earmiR-96Mir96DmdomiRNARNA-seqsupporting cell

Identifiers

PMID38826689
PMCPMC11141775

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.