Evidence map›Paper›PMID 38826460›Full record

ArticlemedRxiv : the preprint server for health sciences2024

EHR-based Case Identification of Pediatric Long COVID: A Report from the RECOVER EHR Cohort.

Morgan Botdorf, Kimberley Dickinson, Vitaly Lorman, Hanieh Razzaghi, Nicole Marchesani, Suchitra Rao, Colin Rogerson, Miranda Higginbotham, Asuncion Mejias, Daria Salyakina and 11 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Morgan BotdorfApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0003-4884-7844
Kimberley DickinsonApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, PA.
Vitaly LormanApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0003-0561-6587
Hanieh RazzaghiApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, PA.
Nicole MarchesaniApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, PA.
Suchitra RaoDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Denver, CO.
Colin RogersonDivision of Critical Care, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0001-5251-2399
Miranda HigginbothamApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, PA.
Asuncion MejiasDivision of Infectious Diseases, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University, Columbus, OH.
Daria SalyakinaCenter for Precision Medicine, Nicklaus Children's Hospital, Miami, FL.
Deepika ThackerNemours Cardiac Center, Alfred I. duPont Hospital for Children, Wilmington, DE.
Dima DandachiDivision of Infectious Diseases, Department of Medicine, University of Missouri-Columbia, Columbia, MO.
Dimitri A ChristakisCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA.
Emily TaylorRECOVER Patient, Caregiver, or Community Representative New York, NY, USA.
Hayden SchwenkDivision of Pediatric Infectious Diseases, Stanford School of Medicine, Palo Alto, CA.
Hiroki MorizonoCenter for Genetic Medicine Research, Children's National Hospital, Washington, DC.ORCID 0000-0002-9678-5564
Jonathan CogenDivision of Pulmonary and Sleep Medicine, Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA.
Nathan M PajorDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati OH.
Ravi JhaveriDivision of Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL.
Christopher B ForrestApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0003-1252-068X
L Charles BaileyApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, PA.

Funding

OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository CoreOT2HL161847 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GROSS, RACHEL SHARON, HORWITZ, LEORA · 2021 to 2025
$651.0M
NHLBI NIH HHS OT2 HL161847
6 · The paper itself

Abstract

Objective: Long COVID, marked by persistent, recurring, or new symptoms post-COVID-19 infection, impacts children's well-being yet lacks a unified clinical definition. This study evaluates the performance of an empirically derived Long COVID case identification algorithm, or computable phenotype, with manual chart review in a pediatric sample. This approach aims to facilitate large-scale research efforts to understand this condition better. Methods: The algorithm, composed of diagnostic codes empirically associated with Long COVID, was applied to a cohort of pediatric patients with SARS-CoV-2 infection in the RECOVER PCORnet EHR database. The algorithm classified 31,781 patients with conclusive, probable, or possible Long COVID and 307,686 patients without evidence of Long COVID. A chart review was performed on a subset of patients (n=651) to determine the overlap between the two methods. Instances of discordance were reviewed to understand the reasons for differences. Results: The sample comprised 651 pediatric patients (339 females, Conclusions: Although there was moderate overlap between the two methods, the discrepancies between the two sources are likely attributed to the lack of consensus on a Long COVID clinical definition. It is essential to consider the strengths and limitations of each method when developing Long COVID classification algorithms.

Indexed as

Chart reviewChronic COVID-19 SyndromeElectronic health recordsElectronic phenotypingLate sequelae of COVID-19Long COVIDLong haul COVIDLong-term COVID-19PEDSnetPost-acute COVID-19Post-acute sequelae SARS-CoV-2 infectionPost COVID syndromeRule-based phenotyping

Identifiers

PMID38826460
PMCPMC11142266

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.