Evidence map›Paper›PMID 38826419›Full record

ArticlebioRxiv : the preprint server for biology2024

Sex specific emergence of trisomic

Jonathan M LaCombe, Kourtney Sloan, Jared R Thomas, Matthew P Blackwell, Isabella Crawford, Joseph M Wallace, Randall J Roper

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jonathan M LaCombeDepartment of Biology, Indiana University-Indianapolis, IN, USA.ORCID 0000-0002-8867-6018
Kourtney SloanDepartment of Biology, Indiana University-Indianapolis, IN, USA.ORCID 0009-0004-3552-6085
Jared R ThomasDepartment of Biology, Indiana University-Indianapolis, IN, USA.
Matthew P BlackwellDepartment of Biology, Indiana University-Indianapolis, IN, USA.
Isabella CrawfordDepartment of Biology, Indiana University-Indianapolis, IN, USA.
Joseph M WallaceDepartment of Biomedical Engineering, Purdue University, Indianapolis, IN, USA.ORCID 0000-0001-6077-8058
Randall J RoperDepartment of Biology, Indiana University-Indianapolis, IN, USA.ORCID 0000-0002-9860-5037

Funding

Strategies for treatment of Down syndrome: Identifying age- and sex-specific developmental windows using inducible genetic reduction of Dyrk1aR01AR078663 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI GOODLETT, CHARLES R., ROPER, RANDALL J · 2020 to 2020
$1.9M
Development and treatment of skeletal deficits in a Down syndrome mouse modelR15HD090603 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI ROPER, RANDALL J · 2017 to 2020
$900k
NIAMS NIH HHS R01 AR078663NICHD NIH HHS R15 HD090603
6 · The paper itself

Abstract

Skeletal insufficiency affects all individuals with Down syndrome (DS) or Trisomy 21 (Ts21) and may alter bone strength throughout development due to a reduced period of bone formation and early attainment of peak bone mass compared to typically developing individuals. Appendicular skeletal deficits also appear in males before females with DS. In femurs of male Ts65Dn DS model mice, cortical deficits were pronounced throughout development, but trabecular deficits and

Indexed as

appendicularbonedevelopmentdosage imbalanceDyrk1aTrisomy 21

Identifiers

PMID38826419
PMCPMC11142220

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.