Evidence map›Paper›PMID 38826394›Full record

ArticlebioRxiv : the preprint server for biology2024

Conserved

Grace Bower, Ethan W Hollingsworth, Sandra Jacinto, Benjamin Clock, Kaitlyn Cao, Mandy Liu, Adam Dziulko, Ana Alcaina-Caro, Qianlan Xu, Dorota Skowronska-Krawczyk and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Grace BowerDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92967, USA.ORCID 0000-0003-1104-604X
Ethan W HollingsworthDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92967, USA.ORCID 0000-0002-5188-3929
Sandra JacintoDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92967, USA.
Benjamin ClockDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92967, USA.ORCID 0000-0003-2968-0727
Kaitlyn CaoDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92967, USA.
Mandy LiuDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92967, USA.
Adam DziulkoEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Ana Alcaina-CaroCentro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Seville, 41013, Spain.ORCID 0000-0002-7352-5890
Qianlan XuDepartment of Physiology and Biophysics, Department of Ophthalmology, Center for Translational Vision Research, School of Medicine, University of California, Irvine, CA, USA.
Dorota Skowronska-KrawczykDepartment of Physiology and Biophysics, Department of Ophthalmology, Center for Translational Vision Research, School of Medicine, University of California, Irvine, CA, USA.ORCID 0000-0002-5758-4225
Javier Lopez-RiosCentro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Seville, 41013, Spain.
Diane E DickelEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Anaïs F BardetInstitut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS UMR7104, INSERM U1258, 67400 Illkirch, France.
Len A PennacchioEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Axel ViselEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Evgeny Z KvonDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92967, USA.ORCID 0000-0002-1562-0945

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Generation of an In Vivo Human Genome Transcriptional Enhancer DatasetR01HG003988 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Len Alexander Pennacchio · 2006 to 2026
$24.1M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
Training Program in Stem Cell Translational Medicine for Neurological DisordersT32NS082174 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PETER John DONOVAN, Leslie Michels Thompson · 2013 to 2026
$3.3M
Deciphering the mechanism of long-range gene regulation in vivoDP2GM149555 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KVON, EVGENY · 2022 to 2025
$2.4M
PacBio RS Single Molecule, Real-Time (SMRT) DNA SequencerS10OD010794 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2012 to 2012
$600k
High-Throughput DNA SequencerS10OD021718 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2016 to 2016
$600k
High Throughput DNA SequencerS10RR025496 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2009 to 2009
$500k
Deciphering Mechanisms of Limb Malformations Caused by Noncoding Variants In VivoF30HD110233 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI Ethan W Hollingsworth · 2022 to 2026
$189k
Characterizing a mechanism of enhancer-promoter interaction in vivoF31HD112201 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI BOWER, GRACE CABOT · 2023 to 2025
$136k
NCI NIH HHS P30 CA062203NCRR NIH HHS S10 RR025496NHGRI NIH HHS R01 HG003988NICHD NIH HHS F30 HD110233NICHD NIH HHS F31 HD112201NIGMS NIH HHS DP2 GM149555NIGMS NIH HHS T32 GM008620NIH HHS S10 OD010794NIH HHS S10 OD021718NINDS NIH HHS T32 NS082174
6 · The paper itself

Abstract

While most mammalian enhancers regulate their cognate promoters over moderate distances of tens of kilobases (kb), some enhancers act over distances in the megabase range. The sequence features enabling such extreme-distance enhancer-promoter interactions remain elusive. Here, we used

Identifiers

PMID38826394
PMCPMC11142232

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.