Evidence map›Paper›PMID 38826385›Full record

ArticlebioRxiv : the preprint server for biology2024

Skeletal muscle myosin heavy chain protein fragmentation as a potential marker of protein degradation in response to resistance training and disuse atrophy.

Daniel L Plotkin, Madison L Mattingly, Derick A Anglin, J Max Michel, Joshua S Godwin, Mason C McIntosh, João G A Bergamasco, Maíra C Scarpelli, Vitor Angleri, Lemuel W Taylor and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Daniel L PlotkinSchool of Kinesiology, Auburn University, Auburn, Alabama, USA.
Madison L MattinglySchool of Kinesiology, Auburn University, Auburn, Alabama, USA.
Derick A AnglinSchool of Kinesiology, Auburn University, Auburn, Alabama, USA.
J Max MichelSchool of Kinesiology, Auburn University, Auburn, Alabama, USA.
Joshua S GodwinSchool of Kinesiology, Auburn University, Auburn, Alabama, USA.
Mason C McIntoshSchool of Kinesiology, Auburn University, Auburn, Alabama, USA.
João G A BergamascoMUSCULAB - Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education, Federal University of São Carlos - UFSCar, São Carlos, SP, Brazil.
Maíra C ScarpelliMUSCULAB - Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education, Federal University of São Carlos - UFSCar, São Carlos, SP, Brazil.
Vitor AngleriMUSCULAB - Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education, Federal University of São Carlos - UFSCar, São Carlos, SP, Brazil.
Lemuel W TaylorSchool of Health Professions, University of Mary Hardin-Baylor, Belton, Texas, USA.
Darryn S WilloughbySchool of Health Professions, University of Mary Hardin-Baylor, Belton, Texas, USA.
C Brooks MobleySchool of Kinesiology, Auburn University, Auburn, Alabama, USA.
Andreas N KavazisSchool of Kinesiology, Auburn University, Auburn, Alabama, USA.
Carlos UgrinowitschSchool of Physical Education and Sport, University of São Paulo - USP, São Paulo, SP, Brazil.
Cleiton A LibardiMUSCULAB - Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education, Federal University of São Carlos - UFSCar, São Carlos, SP, Brazil.
Michael D RobertsSchool of Kinesiology, Auburn University, Auburn, Alabama, USA.

Funding

G-RISE at Auburn UniversityT32GM141739 · NIGMS · AUBURN UNIVERSITY AT AUBURN · PI CLAYTON, TAFFYE BENSON, RUSSELL, MELODY L · 2021 to 2024
$1.2M
NIGMS NIH HHS T32 GM141739
6 · The paper itself

Abstract

We sought to examine how resistance exercise (RE), cycling exercise, and disuse atrophy affect myosin heavy chain (MyHC) protein fragmentation in humans. In the first study (1boutRE), younger adult men (n=8; 5±2 years of RE experience) performed a lower body RE bout with vastus lateralis (VL) biopsies obtained immediately before, 3-, and 6-hours post-exercise. In the second study (10weekRT), VL biopsies were obtained in untrained younger adults (n=36, 18 men and 18 women) before and 24 hours (24h) after their first/naïve RE bout. These participants also engaged in 10 weeks (24 sessions) of resistance training and donated VL biopsies before and 24h after their last RE bout. VL biopsies were also examined from a third acute cycling study (n=7) and a fourth study involving two weeks of leg immobilization (n=20, 15 men and 5 women) to determine how MyHC fragmentation was affected. In the 1boutRE study, the fragmentation of all MyHC isoforms (MyHC

Indexed as

immunoblottingmyosin heavy chainproteolysisresistance exerciseskeletal muscle

Identifiers

PMID38826385
PMCPMC11142278

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.