Evidence map›Paper›PMID 38826378›Full record

ArticlebioRxiv : the preprint server for biology2024

MHConstructor: A high-throughput, haplotype-informed solution to the MHC assembly challenge.

Kristen J Wade, Rayo Suseno, Kerry Kizer, Jacqueline Williams, Juliano Boquett, Stacy Caillier, Nicholas R Pollock, Adam Renschen, Adam Santaniello, Jorge R Oksenberg and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Kristen J WadeWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.ORCID 0000-0002-0338-5028
Rayo SusenoWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.
Kerry KizerWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.
Jacqueline WilliamsWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.
Juliano BoquettWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.
Stacy CaillierWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.
Nicholas R PollockDepartment of Biomedical Informatics, Anschutz Medical Campus, University of Colorado, Aurora, Colorado, USA.
Adam RenschenWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.
Adam SantanielloWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.
Jorge R OksenbergWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.
Paul J NormanDepartment of Biomedical Informatics, Anschutz Medical Campus, University of Colorado, Aurora, Colorado, USA.
Danillo G AugustoDepartment of Biological Sciences, University of North Carolina Charlotte, Charlotte, NC, United States.
Jill A HollenbachWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.

Funding

Insights Into Immune-Related Diseases Born from Population GenomicsU01AI090905 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Paul John Norman · 2010 to 2026
$10.9M
Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic DataR01AI128775 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JILL Allison HOLLENBACH, STEVEN JOHN MACK · 2017 to 2026
$4.5M
NIAID NIH HHS R01 AI128775NIAID NIH HHS U01 AI090905
6 · The paper itself

Abstract

The extremely high levels of genetic polymorphism within the human major histocompatibility complex (MHC) limit the usefulness of reference-based alignment methods for sequence assembly. We incorporate a short read

Indexed as

de novo assemblyhaplotypehuman leukocyte antigen genesMajor histocompatibility complexshort read sequencing

Identifiers

PMID38826378
PMCPMC11142050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.