Evidence map›Paper›PMID 38826363›Full record

ArticlebioRxiv : the preprint server for biology2024

The structure of the SufS-SufE complex reveals interactions driving protected persulfide transfer in iron-sulfur cluster biogenesis.

Rajleen K Gogar, Nidhi Chhikara, Minh Vo, Nathaniel C Gilbert, Jack A Dunkle, Patrick A Frantom

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Rajleen K GogarDepartment of Chemistry & Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487, USA.ORCID 0000-0002-5032-5749
Nidhi ChhikaraDepartment of Chemistry & Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487, USA.ORCID 0009-0005-5484-0384
Minh VoDepartment of Chemistry & Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487, USA.
Nathaniel C GilbertDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, 70803, USA.ORCID 0000-0002-6706-811X
Jack A DunkleDepartment of Chemistry & Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487, USA.ORCID 0000-0001-6252-0587
Patrick A FrantomDepartment of Chemistry & Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487, USA.ORCID 0000-0001-7655-5967

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Conformational dynamics and allosteric regulation during stress-responsive metallocofactor assemblyR01GM112919 · NIGMS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI Patrick Frantom · 2015 to 2026
$2.8M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Determining the specificity and regulation of Type III CRISPR-Cas interferenceR35GM142966 · NIGMS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI DUNKLE, JACK ALBERT · 2021 to 2025
$1.8M
NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM112919NIGMS NIH HHS R35 GM142966NIH HHS S10 OD021527
6 · The paper itself

Abstract

Fe-S clusters are critical cofactors for redox chemistry in all organisms. The cysteine desulfurase, SufS, provides sulfur in the SUF Fe-S cluster bioassembly pathway. SufS is a dimeric, PLP-dependent enzyme that uses cysteine as a substrate to generate alanine and a covalent persulfide on an active site cysteine residue. SufS enzymes are activated by an accessory transpersulfurase protein, either SufE or SufU depending on the organism, which accepts the persulfide product and delivers it to downstream partners for Fe-S assembly. Here, using

Indexed as

cysteine desulfuraseFe-S cluster assembly pathwaypersulfide transfer

Identifiers

PMID38826363
PMCPMC11142160

What OpenQuestion holds

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LicenceCC BY-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.