Evidence map›Paper›PMID 38826301›Full record

ArticlebioRxiv : the preprint server for biology2024

TGF-β Signaling in Cranial Neural Crest Affects Late-Stage Mandibular Bone Resorption and Length.

Claire J Houchen, Saif Ghanem, Vesa Kaartinen, Erin Ealba Bumann

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Claire J HouchenDepartment of Oral and Craniofacial Sciences, University of Missouri-Kansas City School of Dentistry, Kansas City, MO, USA.ORCID 0000-0002-2003-4625
Saif GhanemDepartment Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Vesa KaartinenDepartment Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA.ORCID 0000-0002-9432-510X
Erin Ealba BumannDepartment of Oral and Craniofacial Sciences, University of Missouri-Kansas City School of Dentistry, Kansas City, MO, USA.ORCID 0000-0002-8698-7808

Funding

THE ROLE OF TGF-BETA3 IN PALATOGENESISR01DE013085 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAARTINEN, VESA M · 2001 to 2014
$5.4M
Mesenchymal Regulation of Jaw Bone LengthK08DE021705 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BUMANN, ERIN EALBA · 2011 to 2015
$639k
MicroCT 100S10RR026475 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOHN, DAVID H. · 2010 to 2010
$381k
NCRR NIH HHS S10 RR026475NIDCR NIH HHS K08 DE021705NIDCR NIH HHS R01 DE013085
6 · The paper itself

Abstract

Malocclusions are common craniofacial malformations which cause quality of life and health problems if left untreated. Unfortunately, the current treatment for severe skeletal malocclusion is invasive surgery. Developing improved therapeutic options requires a deeper understanding of the cellular mechanisms responsible for determining jaw bone length. We have recently shown that neural crest mesenchyme (NCM) can alter jaw length by controlling recruitment and function of mesoderm-derived osteoclasts. Transforming growth factor beta (TGF-β) signaling is critical to craniofacial development by directing bone resorption and formation, and heterozygous mutations in TGF-β type I receptor (

Indexed as

bone remodelingbone resorptionjawmandiblemaxillofacial developmentneural crestosteoclastsTransforming Growth Factor-beta Type I Receptor

Identifiers

PMID38826301
PMCPMC11142237

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.