Evidence map›Paper›PMID 38826293›Full record

ArticlebioRxiv : the preprint server for biology2024

Gastrointestinal germinal center B cell depletion and reduction in IgA

Francesca Cossarini, Joan Shang, Azra Krek, Zainab Al-Taie, Ruixue Hou, Pablo Canales-Herrerias, Minami Tokuyama, Michael Tankelevich, Adam Tillowiz, Divya Jha and 25 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors.

Francesca CossariniORCID 0000-0002-8793-5241
Pablo Canales-HerreriasORCID 0000-0002-1865-6476
Michael Tankelevich
Adam Tillowiz
Alexandra E LivanosORCID 0000-0002-8418-3400
Gustavo Martinez-Delgado
Matthew D Taylor
Keshav Sharma
Michael Cruz
Travis Dawson
Seunghee Kim-Schulze
Ahmed Akm
Douglas S Kwon
Sacha Gnjatic
Alexandros D PolydoridesORCID 0000-0001-8604-0756
Carmen Argmann
Ivan Vujkovic-CvijinORCID 0000-0002-8611-4900
Mayte Suarez-FariñasORCID 0000-0001-8712-3553
Francesca Petralia
Saurabh Mehandru

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrointestinal (GI) B cells and plasma cells (PCs) are critical to mucosal homeostasis and the host response to HIV-1 infection. Here, high resolution mapping of human B cells and PCs sampled from the colon and ileum during both viremic and suppressed HIV-1 infection identified a reduction in germinal center (GC) B cells and follicular dendritic cells (FDCs) during HIV-1 viremia. IgA One Sentence Summary: Intestinal germinal center B cell reduction in HIV-1 infection linked to reduced IgA

Identifiers

PMID38826293
PMCPMC11142040

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.