Evidence map›Paper›PMID 38826239›Full record

ArticlebioRxiv : the preprint server for biology2024

Absence of c-Maf and IL-10 enables Type I IFN enhancement of innate responses to low-dose LPS in alveolar macrophages.

Pamelia N Lim, Maritza M Cervantes, Linh K Pham, Sydney Doherty, Ankita Tufts, Divya Dubey, Dat Mai, Alan Aderem, Alan H Diercks, Alissa C Rothchild

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Pamelia N LimDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003.ORCID 0000-0002-1905-8785
Maritza M CervantesDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003.ORCID 0000-0002-5535-3300
Linh K PhamDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003.ORCID 0000-0002-0589-0423
Sydney DohertyDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003.
Ankita TuftsDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003.ORCID 0009-0000-8204-9657
Divya DubeyDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003.ORCID 0000-0002-1376-7425
Dat MaiCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98019.ORCID 0000-0002-3781-8151
Alan AderemCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98019.
Alan H DiercksCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98019.
Alissa C RothchildDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003.ORCID 0000-0001-7484-1193

Funding

IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) - SARS-CoV-2 RELATED RESEARCH75N93019C00070 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI URDAHL, KEVIN · 2019 to 2025
$86.6M
Technology CoreU19AI135976 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI ADEREM, ALAN A, SHERMAN, DAVID R · 2018 to 2022
$17.0M
Biotechnology Training Program in Applied Life SciencesT32GM135096 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Jeanne Ann Hardy, Ashish A. Kulkarni · 2020 to 2026
$3.9M
Nrf2 regulation of alveolar macrophage immune responses in vivo to Mycobacterium tuberculosisR21AI163809 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROTHCHILD, ALISSA CHEN · 2022 to 2023
$429k
NIAID NIH HHS 75N93019C00070NIAID NIH HHS R21 AI163809NIAID NIH HHS U19 AI135976NIGMS NIH HHS T32 GM135096
6 · The paper itself

Abstract

Alveolar macrophages (AMs) are lower-airway resident myeloid cells and are among the first to respond to inhaled pathogens. Here, we interrogate AM innate sensing to Pathogen Associated Molecular Patterns (PAMPs) and determine AMs have decreased responses to low-dose LPS compared to other macrophages, as measured by TNF, IL-6,

Indexed as

Alveolar macrophageCD14c-MafIL-10innate responselipopolysaccharidemyeloid cellsTLR4Type I IFN

Identifiers

PMID38826239
PMCPMC11142172

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.