Evidence map›Paper›PMID 38826231›Full record

ArticlebioRxiv : the preprint server for biology2024

Analyzing high-throughput assay data to advance the rapid screening of environmental chemicals for human reproductive toxicity.

Julia R Varshavsky, Juleen Lam, Courtney Cooper, Patrick Allard, Jennifer Fung, Ashwini Oke, Ravinder Kumar, Joshua F Robinson, Tracey J Woodruff

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Julia R VarshavskyDepartment of Health Sciences and Department of Civil and Environmental Engineering, Northeastern University, Boston, MA.ORCID 0000-0001-6891-7083
Juleen LamDepartment of Public Health, California State University, East Bay, Hayward, CA, USA.
Courtney CooperUniversity of California, San Francisco (UCSF), Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, San Francisco, CA, USA.
Patrick AllardInstitute for Society and Genetics, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID 0000-0001-7765-1547
Jennifer FungCenter for Reproductive Sciences and Department of Obstetrics, Gynecology & Reproductive Sciences, UCSF, San Francisco, CA, USA.
Ashwini OkeCenter for Reproductive Sciences and Department of Obstetrics, Gynecology & Reproductive Sciences, UCSF, San Francisco, CA, USA.
Ravinder KumarCenter for Reproductive Sciences and Department of Obstetrics, Gynecology & Reproductive Sciences, UCSF, San Francisco, CA, USA.
Joshua F RobinsonUniversity of California, San Francisco (UCSF), Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, San Francisco, CA, USA.
Tracey J WoodruffUniversity of California, San Francisco (UCSF), Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, San Francisco, CA, USA.

Funding

UCSF Environmental Research and Translation for Health Center (EaRTH Center)P30ES030284 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JENNIFER C FUNG, Tracey J. Woodruff · 2020 to 2026
$11.2M
Transdisciplinary Approach to Rapidly Identify Reproductive Toxics in Pregnant Women and NewbornsR01ES027051 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Dimitri Abrahamsson, Tracey J. Woodruff · 2016 to 2026
$6.6M
Quantitative Analysis of Meiotic Chromosome Motion and PairingR01GM137126 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FUNG, JENNIFER C · 2020 to 2023
$1.5M
NIEHS NIH HHS P30 ES030284NIEHS NIH HHS R01 ES027051NIGMS NIH HHS R01 GM137126
6 · The paper itself

Abstract

While high-throughput (HTP) assays have been proposed as platforms to rapidly assess reproductive toxicity, there is currently a lack of established assays that specifically address germline development/function and fertility. We assessed the applicability domains of yeast (

Indexed as

aneuploidybenchmark dose modelingbenchmark responsechemical assessmentdevelopmental toxicologygerm cell developmentmeiosisNew Approach Methodologies (NAMs)

Identifiers

PMID38826231
PMCPMC11142090

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.