Evidence map›Paper›PMID 38826230›Full record

ArticlebioRxiv : the preprint server for biology2024

Granzyme K drives a newly-intentified pathway of complement activation.

Carlos A Donado, A Helena Jonsson, Erin Theisen, Fan Zhang, Aparna Nathan, Karishma Vijay Rupani, Dominique Jones, Accelerating Medicines Partnership RA/SLE Network, Soumya Raychaudhuri, Daniel F Dwyer and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Carlos A DonadoDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1093-3088
A Helena JonssonDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Erin TheisenDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Fan ZhangDivision of Rheumatology and the Center for Health Artificial Intelligence, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-6102-2970
Aparna NathanDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Karishma Vijay RupaniDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Dominique JonesDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Accelerating Medicines Partnership RA/SLE Network
Soumya RaychaudhuriDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Daniel F DwyerDivision of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Michael B BrennerDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.

Funding

Role of fibroblastic stromal cells and notch signaling in tissue inflammation in RA and SLEP01AI148102 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael B. Brenner · 2021 to 2026
$17.3M
Training Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8M
DERMATOLOGY TRAINING GRANTT32AR007098 · NIAMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI THOMAS S. KUPPER · 1986 to 2026
$8.1M
Discovery and Functional Impact of Common and Rare Variants in RAR01AR063759 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2013 to 2026
$5.4M
Integrative analysis of high dimensional tissue molecular data to define key biological systems in autoimmune diseases (SBC)UC2AR081023 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2022 to 2026
$4.8M
Newly Identified T Peripheral Helper (Tph) Cells in Rheumatoid ArthritisR01AR073290 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B. · 2018 to 2022
$2.6M
CD8 T cell derived Granzyme K activates complement that drives synovial fibroblast inflammationR01AR081792 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael B. Brenner · 2023 to 2026
$1.4M
Architecture and interactions of Granzyme K+ CD8 T cells in inflamed synovium in rheumatoid arthritisK08AR081412 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Anna Helena Jonsson · 2022 to 2026
$710k
NHGRI NIH HHS T32 HG002295NIAID NIH HHS P01 AI148102NIAMS NIH HHS K08 AR081412NIAMS NIH HHS R01 AR063759NIAMS NIH HHS R01 AR073290NIAMS NIH HHS R01 AR081792NIAMS NIH HHS T32 AR007098NIAMS NIH HHS UC2 AR081023
6 · The paper itself

Abstract

Granzymes are a family of serine proteases mainly expressed by CD8

Identifiers

PMID38826230
PMCPMC11142156

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.