Evidence map›Paper›PMID 38826209›Full record

ArticlebioRxiv : the preprint server for biology2024

Norepinephrine Signals Through Astrocytes To Modulate Synapses.

Katheryn B Lefton, Yifan Wu, Allen Yen, Takao Okuda, Yufen Zhang, Yanchao Dai, Sarah Walsh, Rachel Manno, Joseph D Dougherty, Vijay K Samineni and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Katheryn B LeftonDepartment of Neuroscience, Washington University in St. Louis, 63110, MO, USA.
Yifan WuDepartment of Neuroscience, Washington University in St. Louis, 63110, MO, USA.ORCID 0000-0003-0028-8457
Allen YenDepartment of Genetics, Washington University in St. Louis, 63110, MO, USA.
Takao OkudaDepartment of Anesthesiology, Washington University in St. Louis, 63110, MO, USA.
Yufen ZhangDepartment of Anesthesiology, Washington University in St. Louis, 63110, MO, USA.
Yanchao DaiDepartment of Neuroscience, Washington University in St. Louis, 63110, MO, USA.ORCID 0000-0001-6169-514X
Sarah WalshDepartment of Neuroscience, Washington University in St. Louis, 63110, MO, USA.
Rachel MannoDepartment of Neuroscience, Washington University in St. Louis, 63110, MO, USA.
Joseph D DoughertyDepartment of Genetics, Washington University in St. Louis, 63110, MO, USA.
Vijay K SamineniDepartment of Anesthesiology, Washington University in St. Louis, 63110, MO, USA.ORCID 0000-0002-9491-2793
Paul C SimpsonDeparment of Medicine and Research Service, San Francisco Veterans Affairs Medical Center and Cardiovascular Research Institute, University of California San Francisco, 94143, CA, USA.
Thomas PapouinDepartment of Neuroscience, Washington University in St. Louis, 63110, MO, USA.ORCID 0000-0001-5288-1944

Funding

Regulation of local translation in gliaR01NS102272 · NINDS · WASHINGTON UNIVERSITY · PI JOSEPH D DOUGHERTY · 2017 to 2026
$3.8M
Neural Mechanisms Underlying IC/BPSR01DK128475 · NIDDK · WASHINGTON UNIVERSITY · PI SAMINENI, VIJAY K · 2021 to 2025
$2.3M
Role of astrocyte-based cholinergic neuromodulation in cognition and in the treatment of cognitive disordersR01MH127163 · NIMH · WASHINGTON UNIVERSITY · PI PAPOUIN, THOMAS · 2021 to 2025
$1.9M
NIDDK NIH HHS R01 DK128475NIMH NIH HHS R01 MH127163NINDS NIH HHS R01 NS102272
6 · The paper itself

Abstract

Locus coeruleus (LC)-derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit connectivity, but the underlying synapse-level mechanisms are elusive. Here, we show that NE remodeling of synaptic function is independent from its binding on neuronal receptors. Instead, astrocytic adrenergic receptors and Ca

Identifiers

PMID38826209
PMCPMC11142048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.