Evidence map›Paper›PMID 38826205›Full record

ArticlebioRxiv : the preprint server for biology2024

The Effects of Locus Coeruleus Optogenetic Stimulation on Global Spatiotemporal Patterns in Rats.

Nmachi Anumba, Michael A Kelberman, Wenju Pan, Alexia Marriott, Xiaodi Zhang, Nan Xu, David Weinshenker, Shella Keilholz

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Nmachi AnumbaDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States.
Michael A KelbermanDepartment of Human Genetics, Emory University, Atlanta, GA, United States.
Wenju PanDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States.
Alexia MarriottDepartment of Human Genetics, Emory University, Atlanta, GA, United States.
Xiaodi ZhangDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States.
Nan XuDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States.ORCID 0000-0002-3900-3220
David WeinshenkerDepartment of Human Genetics, Emory University, Atlanta, GA, United States.
Shella KeilholzDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States.

Funding

Training In Systems And Integrative Biology NeuroscienceT32NS096050 · NINDS · EMORY UNIVERSITY · PI Yoland Smith · 2016 to 2026
$3.9M
Impact of locus coeruleus-derived tau pathology in a rodent model of early Alzheimer's diseaseR01AG062581 · NIA · EMORY UNIVERSITY · PI KEILHOLZ, SHELLA D, WEINSHENKER, DAVID · 2020 to 2024
$2.3M
Time-varying spatiotemporal causal interactions in the functional brain networksK99NS123113 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI XU, NAN · 2023 to 2024
$184k
Local and global consequences of hyperphosphorylated tau in the locus coeruleus in Alzheimer's DiseaseF31AG069502 · NIA · EMORY UNIVERSITY · PI KELBERMAN, MICHAEL · 2020 to 2022
$138k
NIA NIH HHS F31 AG069502NIA NIH HHS R01 AG062581NINDS NIH HHS K99 NS123113NINDS NIH HHS T32 NS096050
6 · The paper itself

Abstract

Whole-brain intrinsic activity as detected by resting-state fMRI can be summarized by three primary spatiotemporal patterns. These patterns have been shown to change with different brain states, especially arousal. The noradrenergic locus coeruleus (LC) is a key node in arousal circuits and has extensive projections throughout the brain, giving it neuromodulatory influence over the coordinated activity of structurally separated regions. In this study, we used optogenetic-fMRI in rats to investigate the impact of LC stimulation on the global signal and three primary spatiotemporal patterns. We report small, spatially specific changes in global signal distribution as a result of tonic LC stimulation, as well as regional changes in spatiotemporal patterns of activity at 5 Hz tonic and 15 Hz phasic stimulation. We also found that LC stimulation had little to no effect on the spatiotemporal patterns detected by complex principal component analysis. These results show that the effects of LC activity on the BOLD signal in rats may be small and regionally concentrated, as opposed to widespread and globally acting.

Indexed as

complex principal component analysisglobal signalLocus coeruleusoptogenetic-fMRIquasi-periodic patternsresting state

Identifiers

PMID38826205
PMCPMC11142206

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.