Evidence map›Paper›PMID 38826047›Full record

ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2024

Optical projection tomography implemented for accessibility and low cost (

C Darling, S Kumar, Y Alexandrov, J de Faye, J Almagro Santiago, A Rýdlová, L Bugeon, M J Dallman, A J Behrens, P M W French and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Open, reproducible hardware for microscopy.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2024
    Article
  2. Optical projection tomography implemented for accessibility and low cost (Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

C DarlingPhysics Department, Imperial College London , London SW7 2AZ, UK.
S KumarPhysics Department, Imperial College London , London SW7 2AZ, UK.
Y AlexandrovPhysics Department, Imperial College London , London SW7 2AZ, UK.
J de FayeCancer Stem Cell Laboratory, Institute of Cancer Research , London SW7 3RP, UK.
J Almagro SantiagoCancer Stem Cell Laboratory, Institute of Cancer Research , London SW7 3RP, UK.
A RýdlováDepartment of Life Sciences, Imperial College London , London SW7 2AZ, UK.
L BugeonDepartment of Life Sciences, Imperial College London , London SW7 2AZ, UK.
M J DallmanDepartment of Life Sciences, Imperial College London , London SW7 2AZ, UK.
A J BehrensCancer Stem Cell Laboratory, Institute of Cancer Research , London SW7 3RP, UK.
P M W French *Physics Department, Imperial College London , London SW7 2AZ, UK.
J McGinty *Physics Department, Imperial College London , London SW7 2AZ, UK.

Funding

EPSRC National Productivity Investment FundWellcome Trust FC001999
6 · The paper itself

Abstract

Optical projection tomography (OPT) is a three-dimensional mesoscopic imaging modality that can use absorption or fluorescence contrast, and is widely applied to fixed and live samples in the mm-cm scale. For fluorescence OPT, we present OPT implemented for accessibility and low cost, an open-source research-grade implementation of modular OPT hardware and software that has been designed to be widely accessible by using low-cost components, including light-emitting diode (LED) excitation and cooled complementary metal-oxide-semiconductor (CMOS) cameras. Both the hardware and software are modular and flexible in their implementation, enabling rapid switching between sample size scales and supporting compressive sensing to reconstruct images from undersampled sparse OPT data, e.g. to facilitate rapid imaging with low photobleaching/phototoxicity. We also explore a simple implementation of focal scanning OPT to achieve higher resolution, which entails the use of a fan-beam geometry reconstruction method to account for variation in magnification. This article is part of the Theo Murphy meeting issue 'Open, reproducible hardware for microscopy'.

Indexed as

microscopyopen hardwareopen-sourceoptical projection tomography

Identifiers

PMID38826047
PMCPMC11448604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.