Evidence map›Paper›PMID 38825717›Full record

ArticleJournal of nanobiotechnology2024

Development of

Miguel Toro-González, Ngozi Akingbesote, Amber Bible, Debjani Pal, Brian Sanders, Alexander S Ivanov, Santa Jansone-Popova, Ilja Popovs, Paul Benny, Rachel Perry and 1 more

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Mannosamine-Modified Poly(lactic-Bioconjugate chemistry · 2025
    Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Miguel Toro-GonzálezIsotope Science and Engineering Directorate, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37830, USA.
Ngozi AkingbesoteIsotope Science and Engineering Directorate, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37830, USA.
Amber BibleBiological and Environmental Systems Science Directorate, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37830, USA.
Debjani PalIsotope Science and Engineering Directorate, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37830, USA.
Brian SandersBiological and Environmental Systems Science Directorate, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37830, USA.
Alexander S IvanovPhysical Sciences Directorate, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37830, USA.
Santa Jansone-PopovaPhysical Sciences Directorate, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37830, USA.
Ilja PopovsPhysical Sciences Directorate, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37830, USA.
Paul BennyIsotope Science and Engineering Directorate, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37830, USA.
Rachel PerryDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, 06510, USA.
Sandra DavernIsotope Science and Engineering Directorate, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37830, USA. davernsm@ornl.gov.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Basic Energy Sciences DE-SC00ERKCG21NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Targeted alpha therapy (TAT) relies on chemical affinity or active targeting using radioimmunoconjugates as strategies to deliver α-emitting radionuclides to cancerous tissue. These strategies can be affected by transmetalation of the parent radionuclide by competing ions in vivo and the bond-breaking recoil energy of decay daughters. The retention of α-emitting radionuclides and the dose delivered to cancer cells are influenced by these processes. Encapsulating α-emitting radionuclides within nanoparticles can help overcome many of these challenges. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles are a biodegradable and biocompatible delivery platform that has been used for drug delivery. In this study, PLGA nanoparticles are utilized for encapsulation and retention of actinium-225 ([

Indexed as

ActiniumNanoparticlesPolylactic Acid-Polyglycolic Acid CopolymerAlpha ParticlesAnimalsBiocompatible MaterialsBreast NeoplasmsCell Line, TumorFemaleHumansMiceRadioimmunotherapyActiniumActinium-225Biocompatible MaterialsPolylactic Acid-Polyglycolic Acid CopolymerActinium-225LigandNanoparticlesPoly(lactic-co-glycolic acid)Therapy

Identifiers

PMID38825717
PMCPMC11145892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.