Evidence map›Paper›PMID 38825715›Full record

ArticleBMC biotechnology2024

Minimizing IP issues associated with gene constructs encoding the Bt toxin - a case study.

Md Mahmudul Hassan, Francis Tenazas, Adam Williams, Jing-Wen Chiu, Charles Robin, Derek A Russell, John F Golz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Md Mahmudul HassanSchool of Biosciences, University of Melbourne, Parkville, VIC, 3010, Australia.
Francis TenazasSchool of Biosciences, University of Melbourne, Parkville, VIC, 3010, Australia.
Adam WilliamsSchool of Biosciences, University of Melbourne, Parkville, VIC, 3010, Australia.
Jing-Wen ChiuSchool of Agriculture, Food and Ecosystem Sciences, University of Melbourne, Parkville, VIC, 3010, Australia.
Charles RobinSchool of Biosciences, University of Melbourne, Parkville, VIC, 3010, Australia.
Derek A RussellMelbourne Veterinary School, University of Melbourne, Parkville, VIC, 3010, Australia.
John F GolzSchool of Biosciences, University of Melbourne, Parkville, VIC, 3010, Australia. jgolz@unimelb.edu.au.

Funding

Transgenic Mouse and Biobank CoreP01CA095616 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DEPINHO, RONALD ANTHONY · 2003 to 2012
$20.3M
Australia-India Strategic Research Fund GCF010009NCI NIH HHS P01 CA095616
6 · The paper itself

Abstract

backgroundAs part of a publicly funded initiative to develop genetically engineered Brassicas (cabbage, cauliflower, and canola) expressing Bacillus thuringiensis Crystal (Cry)-encoded insecticidal (Bt) toxin for Indian and Australian farmers, we designed several constructs that drive high-level expression of modified Cry1B and Cry1C genes (referred to as Cry1B

resultsTo assess the insecticidal efficacy of the Cry1B

conclusionsOur work indicates that the modified Cry1 genes are suitable for the development of insect resistant GM crops. Except for the PAT gene in the USA, our assessment of the intellectual property landscape of components presents within the constructs described here suggest that they can be used without the need for further licensing. This has the capacity to significantly reduce the cost of developing and using these Cry1

Indexed as

ArabidopsisBacillus thuringiensis ToxinsBacterial ProteinsEndotoxinsHemolysin ProteinsPlants, Genetically ModifiedAnimalsBacillus thuringiensisBrassicaInsecticidesMothsPest Control, BiologicalPromoter Regions, GeneticBacillus thuringiensis ToxinsBacterial ProteinsEndotoxinsHemolysin Proteinsinsecticidal crystal protein, Bacillus ThuringiensisInsecticidesBacillus thuringiensisBt toxinCry1BCry1CCry1 MDiamondback mothGene stackingInsecticidal gene

Identifiers

PMID38825715
PMCPMC11145813

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.