Evidence map›Paper›PMID 38825686›Full record

ArticleJournal of orthopaedic surgery and research2024

Involvement of RAMP1/p38MAPK signaling pathway in osteoblast differentiation in response to mechanical stimulation: a preliminary study.

Thunwa Binlateh, Chidchanok Leethanakul, Peungchaleoy Thammanichanon

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In one paragraph

Article in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Thunwa BinlatehSchool of Pharmacy, Walailak University, Nakhon Si Thammarat, Thailand.
Chidchanok LeethanakulOrthodontic Section, Department of Preventive Dentistry, Faculty of Dentistry, Prince of Songkla University, Songkhla, Thailand.
Peungchaleoy ThammanichanonInstitute of Dentistry, Suranaree University of Technology, Nakhon Ratchasima, Thailand. chaleoy@g.sut.ac.th.

Funding

Suranaree University of Technology, Thailand Science Research and Innovation (TSRI), and National Science, Research, and Innovation Fund 4285350
6 · The paper itself

Abstract

objectiveThe present study aimed to investigate the underlying mechanism of mechanical stimulation in regulating osteogenic differentiation. MATERIALS AND

methodsOsteoblasts were exposed to compressive force (0-4 g/cm

resultsUsing compressive force treatments, low magnitudes (1 and 2 g/cm

conclusionThese findings suggest that CGRP-RAMP1/p38MAPK signaling implicates in osteoblast differentiation in response to optimal magnitude of compressive force. This study helps to define the underlying mechanism of compressive stimulation and may also enhance the application of compressive stimulation or CGRP peptide as an alternative approach for accelerating tooth movement in orthodontic treatment.

Indexed as

Cell DifferentiationOsteoblastsOsteogenesisp38 Mitogen-Activated Protein KinasesReceptor Activity-Modifying Protein 1Calcitonin Gene-Related PeptideCells, CulturedCore Binding Factor Alpha 1 SubunitHumansMAP Kinase Signaling SystemOsteocalcinSignal TransductionStress, MechanicalCalcitonin Gene-Related PeptideCore Binding Factor Alpha 1 SubunitOsteocalcinp38 Mitogen-Activated Protein KinasesRAMP1 protein, humanReceptor Activity-Modifying Protein 1CGRPMechanical loadingOsteoblastRAMP1

Identifiers

PMID38825686
PMCPMC11145863

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.