SynthesisEuropean radiology experimental2024
Advances and prospects in deuterium metabolic imaging (DMI): a systematic review of in vivo studies.
Synthesis in European radiology experimental, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Physics-embedded CycleGAN for robust metabolite mapping in short-readout deuterium metabolic imaging.Magnetic resonance letters · 2026Article
- Atlas of Brain Glucose Metabolism Using Deuterium Metabolic Imaging at 3 T.Magnetic resonance in medicine · 2026Article
- MR-based techniques for imaging prostate cancer metabolism: current status and future perspectives.Abdominal radiology (New York) · 2026Review
- Unraveling the role of deuterium in cancer: mechanisms, detection techniques, and therapeutic potential.Molecular diversity · 2026Review
- High-spatiotemporal resolution deuterium metabolic imaging enables in vivo phenotyping of intra- and intertumoral heterogeneity.Science advances · 2026Article
- On the Origin of the Brain Semi-Heavy Water Deuterium MR Signal Following Administration of Deuterated Metabolic Substrate: A Cautionary Tale.Magnetic resonance in medicine · 2026Article
- Dynamic deuterium metabolic imaging in glioblastoma at 7T.Magma (New York, N.Y.) · 2026Article
- Absolute Quantification of Brain Deuterium Metabolic Imaging in Healthy Volunteers and Glioblastoma Patients at 7T.Magnetic resonance in medicine · 2026Article
- Deuterium 1-Channel Transmit/16-Channel High Impedance Receive Array Combined With 16-ChannelMagnetic resonance in medicine · 2026Article
- Article
- Quantification of fractional tumor burden for the early detection of post-treatment glioblastoma progression.European radiology experimental · 2026Article
- Review
- Review
- Metabolic Shift Mirrors GBM Immunity to Anti-PD-L1 Immunotherapy: A Deuterium MRS Study.Molecular imaging and biology · 2025Article
- Quantitative mapping of key glucose metabolic rates in the human brain using dynamic deuterium magnetic resonance spectroscopic imaging.PNAS nexus · 2025Article
- Advances inFrontiers in endocrinology · 2025Review
- Deuterium magnetic resonance imaging of tumors using low-dose systemic deuterated water labeling.Frontiers in oncology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
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Abstract
backgroundDeuterium metabolic imaging (DMI) has emerged as a promising non-invasive technique for studying metabolism in vivo. This review aims to summarize the current developments and discuss the futures in DMI technique in vivo.
methodsA systematic literature review was conducted based on the PRISMA 2020 statement by two authors. Specific technical details and potential applications of DMI in vivo were summarized, including strategies of deuterated metabolites detection, deuterium-labeled tracers and corresponding metabolic pathways in vivo, potential clinical applications, routes of tracer administration, quantitative evaluations of metabolisms, and spatial resolution.
resultsOf the 2,248 articles initially retrieved, 34 were finally included, highlighting 2 strategies for detecting deuterated metabolites: direct and indirect DMI. Various deuterated tracers (e.g., [6,6'-
conclusionsEnhancing spatial resolution can facilitate the clinical translation of DMI. Furthermore, optimizing tracer synthesis, administration protocols, and quantification methodologies will further enhance their clinical applicability. RELEVANCE STATEMENT: Deuterium metabolic imaging, a promising non-invasive technique, is systematically discussed in this review for its current progression, limitations, and future directions in studying in vivo energetic metabolism, displaying a relevant clinical potential. KEY POINTS: • Deuterium metabolic imaging (DMI) shows promise for studying in vivo energetic metabolism. • This review explores DMI's current state, limits, and future research directions comprehensively. • The clinical translation of DMI is mainly impeded by limitations in spatial resolution.
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