Article in The Journal of rheumatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
16 authors.
Barbara Pontes AiresB. Pontes Aires, MD, Department of Pediatrics, Tufts Medical Center, Tufts University School of Medicine, and Department of Pediatrics, Boston Children's Hospital.ORCID 0000-0002-9821-8459
Holly WobmaH. Wobma, MD, PhD, M.T. Chandler, MD, MPH, M.H. Chang, MD, PhD, F. Dedeoglu, MD, O. Halyabar, MD, M.B.F. Son, MD, L.A. Henderson, MD, MMSc, Division of Immunology, Boston Children's Hospital, Harvard Medical School.ORCID 0000-0001-8978-3184
Aaida SamadA. Samad, MD, M.P. Fishman, MD, T. Klouda, DO, J. Levin, MD, MBI, A. Casey, MD, Division of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School.
Mia T ChandlerH. Wobma, MD, PhD, M.T. Chandler, MD, MPH, M.H. Chang, MD, PhD, F. Dedeoglu, MD, O. Halyabar, MD, M.B.F. Son, MD, L.A. Henderson, MD, MMSc, Division of Immunology, Boston Children's Hospital, Harvard Medical School.ORCID 0000-0003-2223-0061
Margaret H ChangH. Wobma, MD, PhD, M.T. Chandler, MD, MPH, M.H. Chang, MD, PhD, F. Dedeoglu, MD, O. Halyabar, MD, M.B.F. Son, MD, L.A. Henderson, MD, MMSc, Division of Immunology, Boston Children's Hospital, Harvard Medical School.ORCID 0000-0002-3545-8957
Fatma DedeogluH. Wobma, MD, PhD, M.T. Chandler, MD, MPH, M.H. Chang, MD, PhD, F. Dedeoglu, MD, O. Halyabar, MD, M.B.F. Son, MD, L.A. Henderson, MD, MMSc, Division of Immunology, Boston Children's Hospital, Harvard Medical School.ORCID 0000-0002-7516-0848
Martha P FishmanA. Samad, MD, M.P. Fishman, MD, T. Klouda, DO, J. Levin, MD, MBI, A. Casey, MD, Division of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School.ORCID 0000-0002-0083-0501
Timothy KloudaA. Samad, MD, M.P. Fishman, MD, T. Klouda, DO, J. Levin, MD, MBI, A. Casey, MD, Division of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School.ORCID 0000-0002-8485-9773
Jonathan LevinA. Samad, MD, M.P. Fishman, MD, T. Klouda, DO, J. Levin, MD, MBI, A. Casey, MD, Division of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School.ORCID 0000-0002-8422-791X
Olha HalyabarH. Wobma, MD, PhD, M.T. Chandler, MD, MPH, M.H. Chang, MD, PhD, F. Dedeoglu, MD, O. Halyabar, MD, M.B.F. Son, MD, L.A. Henderson, MD, MMSc, Division of Immunology, Boston Children's Hospital, Harvard Medical School.ORCID 0000-0002-3117-173X
Susan F SaleebS.F. Saleeb, MD, W. Tworetzky, MD, J.W. Newburger, MD, MPH, Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-4919-6097
Wayne TworetzkyS.F. Saleeb, MD, W. Tworetzky, MD, J.W. Newburger, MD, MPH, Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-8422-2158
Mary Beth F SonH. Wobma, MD, PhD, M.T. Chandler, MD, MPH, M.H. Chang, MD, PhD, F. Dedeoglu, MD, O. Halyabar, MD, M.B.F. Son, MD, L.A. Henderson, MD, MMSc, Division of Immunology, Boston Children's Hospital, Harvard Medical School.ORCID 0000-0002-7394-2862
Jane W NewburgerS.F. Saleeb, MD, W. Tworetzky, MD, J.W. Newburger, MD, MPH, Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-7794-9017
Alicia CaseyA. Samad, MD, M.P. Fishman, MD, T. Klouda, DO, J. Levin, MD, MBI, A. Casey, MD, Division of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School.ORCID 0000-0002-3566-9690
Lauren A HendersonH. Wobma, MD, PhD, M.T. Chandler, MD, MPH, M.H. Chang, MD, PhD, F. Dedeoglu, MD, O. Halyabar, MD, M.B.F. Son, MD, L.A. Henderson, MD, MMSc, Division of Immunology, Boston Children's Hospital, Harvard Medical School; lauren.henderson@childrens.harvard.edu.ORCID 0000-0003-0242-4029
Funding
MOLECULAR BASIS OF ALLERGIC AND IMMUNOLOGIC DISEASET32AI007512 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI Janet Chou, Peter A Nigrovic · 1996 to 2026
$13.1M
Joint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4M
T peripheral regulatory cells as modulators of T cell-B cell interactions in arthritisR01AR083424 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI Lauren A Henderson · 2024 to 2026
objectiveTo describe the clinical features of patients with congenital heart disease (CHD) who subsequently developed systemic juvenile idiopathic arthritis (sJIA).
methodsWe conducted a retrospective review of patients diagnosed with CHD and sJIA at our institution. Detailed clinical, laboratory, and radiographic data were collected from the medical record and reviewed with each patient's primary medical team.
resultsFive patients with sJIA and CHD were identified. Each child had a unique cardiac anatomy, but all the patients required surgical repair during the first year of life. Four children had thymectomies at the time of cardiac surgery. Classic signs of sJIA such as fever (n = 5), rash (n = 5), and arthritis (n = 4) developed after surgical intervention in all the patients. The individuals in this cohort displayed risk factors associated with severe sJIA, including disease onset before 2 years of age (n = 5), elevated interleukin 18 levels (n = 5), baseline eosinophilia prior to initiation of biologic disease-modifying antirheumatic drugs (n = 4), and positivity for HLA-DRB1*15:01 alleles (n = 4). Macrophage activation syndrome (MAS) occurred in 3 patients and sJIA-associated lung disease (sJIA-LD) was identified in 4 patients. Two children died from complications of their cardiac and/or pulmonary disease.
conclusionWe identified an association between CHD and severe forms of sJIA. Although these findings will need to be confirmed in larger, multicenter cohorts, the results highlight the importance of considering a diagnosis of sJIA in children with CHD and remaining vigilant for complications such as MAS and sJIA-LD.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Severe Features of Systemic Juvenile Idiopathic Arthritis in Patients With Congenital Heart Disease. · full record | OpenQuestion