Evidence map›Paper›PMID 38825354›Full record

ArticleThe Journal of rheumatology2024

Reproductive Outcomes for Women With Vasculitis.

Catherine A Sims, Amanda M Eudy, Kalen Larson, Christine Yeung, Heather Tam, Joyce Kullman, Renée L Borchin, Cristina Burroughs, Peter A Merkel, Megan E B Clowse and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of rheumatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02593565 (The Vasculitis Pregnancy Registry), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02593565 recruitingnot on this map

The Vasculitis Pregnancy Registry (V-PREG)

Typeobservational_patient_registrySponsorUniversity of PennsylvaniaRan2015 to 2027Enrolled100ConditionsVasculitis, Behcet's Disease, CNS Vasculitis, Cryoglobulinemic VasculitisArmsOnline questionnaires
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Catherine A SimsC.A. Sims, MD, Durham Veterans Affairs Healthcare System, Division of Rheumatology & Immunology, Duke University, Durham, North Carolina; cas206@duke.edu.
Amanda M EudyA.M. Eudy, PhD, Department of Medicine, Duke University, Durham, North Carolina.ORCID 0000-0002-3107-5545
Kalen LarsonK. Larson, MA, J. Kullman, Vasculitis Foundation, Kansas City, Missouri.
Christine YeungC. Yeung, BS, Vasculitis Patient-Powered Research Network, University of Pennsylvania, Division of Rheumatology, Philadelphia, Pennsylvania.
Heather TamH. Tam, Patient Advocate, Vasculitis Patient-Powered Research Network, University of Pennsylvania, Division of Rheumatology, Philadelphia, Pennsylvania.
Joyce KullmanK. Larson, MA, J. Kullman, Vasculitis Foundation, Kansas City, Missouri.
Renée L BorchinR.L. Borchin, BSW, C. Burroughs, BS, Health Informatics Institute, University of South Florida, Tampa, Florida.
Cristina BurroughsR.L. Borchin, BSW, C. Burroughs, BS, Health Informatics Institute, University of South Florida, Tampa, Florida.
Peter A MerkelP.A. Merkel, MD, MPH, Division of Rheumatology, Department of Medicine, and Division of Epidemiology, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania.
Megan E B Clowse
VPREG Collaborative Group

Funding

K24 Advancing Reproductive RheumatologyK24AR084072 · NIAMS · DUKE UNIVERSITY · PI Megan E.B. Clowse · 2024 to 2026
$472k
NIAMS NIH HHS K24 AR084072
6 · The paper itself

Abstract

objectiveThere are limited data on the reproductive health of women with vasculitis. This study used a prospective, international vasculitis pregnancy registry to survey women during and after pregnancy.

methodsThe Vasculitis Pregnancy Registry (VPREG) is imbedded within the Vasculitis Patient-Powered Research Network, an international online research infrastructure. Any pregnant woman with a diagnosis of vasculitis can self-enroll. After enrollment, women are invited to complete online surveys at study entry, once per trimester, and postpartum. Descriptive statistics are reported here.

resultsBetween 2015 and 2022, 147 women with 149 pregnancies enrolled in VPREG from 16 countries. Data on 78 pregnancies with known outcomes were included in this analysis. During pregnancy, women on average experienced low levels of pain related to vasculitis (scale 0-10, median 2 [IQR 1-5]) and preserved feelings of wellness (scale 0-10, median 3 [IQR 1-5]). Thirty-six percent of women reported their vasculitis was active during pregnancy. Of the 14 women requiring hospitalization during pregnancy outside of delivery, 4 cited active vasculitis as the indication. Most women (54/73, 74%) were prescribed medications for vasculitis during pregnancy. Seventy-six (97%) pregnancies resulted in live births, with 64% delivering vaginally and 21% experiencing a preterm delivery.

conclusionThese results demonstrate that most women with vasculitis can experience pregnancies that result in live births delivered at term. During pregnancy, a minority of women reported flares of vasculitis or the need for hospitalization due to vasculitis. These data are useful to rheumatologists and patients to inform and facilitate discussions about reproductive health and vasculitis.

Indexed as

Pregnancy OutcomeRegistriesVasculitisAdultFemaleHumansPregnancyPregnancy Complications, CardiovascularProspective Studiespregnancyreproductive healthcarevasculitiswomen’s health

Identifiers

PMID38825354
PMCPMC13173927

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.