Evidence map›Paper›PMID 38825188›Full record

ArticleMolecules and cells2024

Actin depolymerizing factor destrin governs cell migration in neural development during Xenopus embryogenesis.

Youni Kim, Hyun-Kyung Lee, Kyeong-Yeon Park, Tayaba Ismail, Hongchan Lee, Hong-Yeoul Ryu, Dong-Hyung Cho, Taeg Kyu Kwon, Tae Joo Park, Taejoon Kwon and 1 more

Abstract read
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In one paragraph

Article in Molecules and cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Youni KimKNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea.
Hyun-Kyung LeeKNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea.
Kyeong-Yeon ParkKNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea.
Tayaba IsmailKNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea.
Hongchan LeeKNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea.
Hong-Yeoul RyuKNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea.
Dong-Hyung ChoKNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea.
Taeg Kyu KwonDepartment of Immunology, School of Medicine, Keimyung University, Daegu 41566, Korea.
Tae Joo ParkDepartment of Biological Sciences, College of Information-Bio Convergence, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea.
Taejoon KwonDepartment of Biomedical Engineering, College of Information-Bio Convergence, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea.
Hyun-Shik LeeKNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea. Electronic address: leeh@knu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The actin-based cytoskeleton is considered a fundamental driving force for cell differentiation and development. Destrin (Dstn), a member of the actin-depolymerizing factor family, regulates actin dynamics by treadmilling actin filaments and increasing globular actin pools. However, the specific developmental roles of dstn have yet to be fully elucidated. Here, we investigated the physiological functions of dstn during early embryonic development using Xenopus laevis as an experimental model organism. dstn is expressed in anterior neural tissue and neural plate during Xenopus embryogenesis. Depleting dstn promoted morphants with short body axes and small heads. Moreover, dstn inhibition extended the neural plate region, impairing cell migration and distribution during neurulation. In addition to the neural plate, dstn knockdown perturbed neural crest cell migration. Our data suggest new insights for understanding the roles of actin dynamics in embryonic neural development, simultaneously presenting a new challenge for studying the complex networks governing cell migration involving actin dynamics.

Indexed as

Cell MovementDestrinEmbryonic DevelopmentXenopus laevisActinsAnimalsGene Expression Regulation, DevelopmentalNeural CrestNeural PlateNeurogenesisXenopus ProteinsActinsDestrinXenopus ProteinsDestrinF-actinNeural crestNeurulationXenopus laevis

Identifiers

PMID38825188
PMCPMC11227013

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.