Evidence map›Paper›PMID 38824840›Full record

ReviewCurrent opinion in microbiology2024

Host-microbe interactions: communication in the microbiota-gut-brain axis.

Aryan Shekarabi, Izhan Qureishy, Chloe H Puglisi, Marge Dalseth, Helen E Vuong

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aryan ShekarabiUniversity of Minnesota Twin-Cities, Department of Pediatrics, Neonatology Division, USA.
Izhan QureishyUniversity of Minnesota Twin-Cities, Department of Pediatrics, Neonatology Division, USA.
Chloe H PuglisiUniversity of Minnesota Twin-Cities, Department of Pediatrics, Neonatology Division, USA.
Marge DalsethUniversity of Minnesota Twin-Cities, Department of Pediatrics, Neonatology Division, USA.
Helen E VuongUniversity of Minnesota Twin-Cities, Department of Pediatrics, Neonatology Division, USA. Electronic address: hevuong@umn.edu.

Funding

Investigating role of maternal gut microbiome in microglia-neuron dynamics and development of somatosensory circuitsR00HD101680 · NICHD · UNIVERSITY OF MINNESOTA · PI VUONG, HELEN · 2022 to 2024
$721k
NICHD NIH HHS R00 HD101680
6 · The paper itself

Abstract

Animals harbor a diverse array of symbiotic micro-organisms that coexist in communities across different body sites. These microbes maintain host homeostasis and respond to environmental insults to impact host physiological processes. Trillions of indigenous microbes reside in the gastrointestinal tract and engage with the host central nervous system (microbiota-gut-brain axis) by modulating immune responses, interacting with gut intrinsic and extrinsic nervous system, and regulating neuromodulators and biochemicals. These gut microbiota to brain signaling pathways are constantly informed by each other and are hypothesized to mediate brain health across the lifespan. In this review, we will examine the crosstalk of gut microbiota to brain communications in neurological pathologies, with an emphasis on microbial metabolites and neuromodulators, and provide a discussion of recent advances that help elucidate the microbiota as a therapeutic target for treating brain and behavioral disorders.

Indexed as

Brain-Gut AxisGastrointestinal MicrobiomeHost Microbial InteractionsAnimalsBrainGastrointestinal TractHumans

Identifiers

PMID38824840
PMCPMC11323153

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.