Evidence map›Paper›PMID 38824659›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance.

Leanne Howard, Carla Abdelnour, Erin L Abner, Ricardo F Allegri, Hiroko H Dodge, Serge Gauthier, Camilla M Hoyos, Gregory A Jicha, Patrick G Kehoe, Catherine J Mummery and 7 more

Abstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Celebrating 40 years of the University of Kentucky Alzheimer's Disease Research Center.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  3. Article
  4. Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Leanne HowardBrain Health, The George Institute for Global Health, Sydney, New South Wales, Australia.
Carla AbdelnourDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, USA.
Erin L AbnerDepartment of Epidemiology and Environmental Health, University of Kentucky, Lexington, USA.
Ricardo F AllegriDepartament of Cognitive Neurology, Neuropsychology, and Neuropsychiatry, Instituto de Investigaciones Neurologicas Fleni, Buenos Aires, Argentina.
Hiroko H DodgeDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
Serge GauthierDepartment of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada.
Camilla M HoyosMedicine, Human and Health Sciences, Macquarie University, Sydney, NSW, Australia.
Gregory A JichaDepartment of Epidemiology and Environmental Health, University of Kentucky, Lexington, USA.
Patrick G KehoeTranslational Health Sciences, Bristol Medical School University of Bristol, Bristol, UK.
Catherine J MummeryNeurodegenerative Diseases, University College London, London, UK.
Adesola OgunniyiDepartment of Medicine, University of Ibadan, Ibadan, Nigeria.
Nikolaos Scarmeas1st Department of Neurology, Aiginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Xiaoying ChenBrain Health, The George Institute for Global Health, Sydney, New South Wales, Australia.
Jodie R TitinerInternational Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association, Chicago, USA.
Christopher R WeberInternational Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association, Chicago, USA.
Clinical Trial Methodology Working review group members
Ruth PetersBrain Health, The George Institute for Global Health, Sydney, New South Wales, Australia.ORCID 0000-0003-0148-3617

Funding

University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART)Clinical Trials Advancement and Methods Professional Interest AreaNIA NIH HHS P30 AG072946
6 · The paper itself

Abstract

introductionRecent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralized clinical trials in dementia. There are many potential benefits associated with decentralized medication trials, but we currently lack specific recommendations for their delivery in the dementia field.

methodsA modified Delphi method engaged an expert panel to develop recommendations for the conduct of decentralized medication trials in dementia prevention. A working group of researchers and clinicians with expertise in dementia trials further refined the recommendations.

resultsOverall, the recommendations support the delivery of decentralized trials in dementia prevention provided adequate safety checks and balances are included. A total of 40 recommendations are presented, spanning aspects of decentralized clinical trials, including safety, dispensing, outcome assessment, and data collection. DISCUSSION: These recommendations provide an accessible, pragmatic guide for the design and conduct of remote medication trials for dementia prevention. HIGHLIGHTS: Clinical trials of medication have begun adopting decentralized approaches. Researchers in the field lack guidance on what would be appropriate circumstances and frameworks for what would be appropriate circumstances and frameworks for the use of decentralized trial methods in dementia prevention. The present report provides consensus-based expert recommendations for decentralized clinical trials for dementia prevention.

Indexed as

Clinical Trials as TopicDementiaDelphi TechniqueHumansResearch Designdecentralized clinical trialsDelphi processdementia preventionrecommendationsremote clinical trials

Identifiers

PMID38824659
PMCPMC11247660

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.