Evidence map›Paper›PMID 38824603›Full record

ReviewJournal of hematology & oncology2024

Novel clinical risk stratification and treatment strategies in relapsed/refractory peripheral T-cell lymphoma.

Esther Wei Yin Chang, Ya Hwee Tan, Jason Yongsheng Chan

Abstract readReview
In one paragraph

Review in Journal of hematology & oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Esther Wei Yin ChangDivision of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore. esther.chang.w.y@singhealth.com.sg.
Ya Hwee TanDivision of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
Jason Yongsheng ChanDivision of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore. jason.chan.y.s@singhealth.com.sg.

Funding

Singapore Ministry of Health's National Medical Research Council RTF Seed Fund (SEEDFD21jun-0002)SingHealth Duke-NUS AM/ACP-Designated Philanthropic Fund Grant Award 08/FY2023/EX/27-A65
6 · The paper itself

Abstract

Peripheral T cell lymphoma (PTCL) represents a group of heterogeneous hematological malignancies, which are notoriously challenging to treat and outcomes are typically poor. Over the past two decades, clinical prognostic indices for patient risk stratification have evolved, while several targeted agents are now available to complement combination chemotherapy in the frontline setting or as a salvage strategy. With further understanding of the molecular pathobiology of PTCL, several innovative approaches incorporating immunomodulatory agents, epigenetic therapies, oncogenic kinase inhibitors and immunotherapeutics have come to the forefront. In this review, we provide a comprehensive overview of the progress in developing clinical prognostic indices for PTCL and describe the broad therapeutic landscape, emphasizing novel targetable pathways that have entered early phase clinical studies.

Indexed as

Lymphoma, T-Cell, PeripheralAntineoplastic Combined Chemotherapy ProtocolsHumansImmunotherapyMolecular Targeted TherapyNeoplasm Recurrence, LocalPrognosisRisk AssessmentAITLEpigeneticsImmunotherapyPrecision OncologyPrognosis

Identifiers

PMID38824603
PMCPMC11144347

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.