Evidence map›Paper›PMID 38824565›Full record

ArticleBMC oral health2024

An innovative cell-based transplantation therapy for an immature permanent tooth in an adult: a case report.

Keyue Liu, Wenxu Li, Sijing Yu, Guimin Li, Ling Ye, Bo Gao

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Keyue LiuState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dentistry and Endodontics Department, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Wenxu LiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dentistry and Endodontics Department, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Sijing YuState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dentistry and Endodontics Department, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Guimin LiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dentistry and Endodontics Department, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Ling YeState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dentistry and Endodontics Department, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Bo GaoState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dentistry and Endodontics Department, West China Hospital of Stomatology, Sichuan University, Chengdu, China. gaob@scu.edu.cn.

Funding

Sichuan Province Science and Technology Support Program 2023NSFSC0575
6 · The paper itself

Abstract

backgroundImmature teeth with necrotic pulps present multiple challenges to clinicians. In such cases, regenerative endodontic procedures (REPs) may be a favorable strategy. Cells, biomaterial scaffolds, and signaling molecules are three key elements of REPs. Autologous human dental pulp cells (hDPCs) play an important role in pulp regeneration. In addition, autologous platelet concentrates (APCs) have recently been demonstrated as effective biomaterial scaffolds in regenerative dentistry, whereas the latest generation of APCs-concentrated growth factor (CGF), especially liquid phase CGF (LPCGF)-has rarely been reported in REPs. CASE PRESENTATION: A 31-year-old woman presented to our clinic with the chief complaint of occlusion discomfort in the left mandibular posterior region for the past 5 years. Tooth #35 showed no pulp vitality and had a periodontal lesion, and radiographic examination revealed that the tooth exhibited extensive periapical radiolucency with an immature apex and thin dentin walls. REP was implemented via transplantation of autologous hDPCs with the aid of LPCGF. The periodontal lesion was managed with simultaneous periodontal surgery. After the treatment, the tooth was free of any clinical symptoms and showed positive results in thermal and electric pulp tests at 6- and 12-month follow-ups. At 12-month follow-up, radiographic evidence and three-dimensional models, which were reconstructed using Mimics software based on cone-beam computed tomography, synergistically confirmed bone augmentation and continued root development, indicating complete disappearance of the periapical radiolucency, slight lengthening of the root, evident thickening of the canal walls, and closure of the apex.

conclusionhDPCs combined with LPCGF represents an innovative and effective strategy for cell-based regenerative endodontics.

Indexed as

Dental PulpRegenerative EndodonticsAdultCell TransplantationDental Pulp NecrosisFemaleHumansTransplantation, AutologousAutologous human dental pulp cellsCase reportCell-based transplantation therapyLiquid phase concentrated growth factorRegenerative endodontic procedure

Identifiers

PMID38824565
PMCPMC11143573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.