Evidence map›Paper›PMID 38824519›Full record

ArticleBMC neurology2024

Strength together: examining risk and protective factors associated with dementia and cognitive impairment in Aboriginal and Torres Strait Islander peoples through harmonisation of landmark studies.

Huong X T Nguyen, Zoë Hyde, Bridgette J McNamara, Jo-Anne Hughson, Kylie Radford, Sarah Russell, Leon Flicker, Rachel Quigley, Roslyn Malay, Edward Strivens and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Huong X T NguyenDepartment of Medicine - Royal Melbourne Hospital, The University of Melbourne, Royal Park Campus, Administration Building 21, 34 -54 Poplar Road, Melbourne, VIC, 3050, Australia. huong.x.nguyen@mh.org.au.
Zoë HydeDepartment of Medicine - Royal Melbourne Hospital, The University of Melbourne, Royal Park Campus, Administration Building 21, 34 -54 Poplar Road, Melbourne, VIC, 3050, Australia.
Bridgette J McNamaraCentre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, VIC, Australia.
Jo-Anne HughsonDepartment of Medicine - Royal Melbourne Hospital, The University of Melbourne, Royal Park Campus, Administration Building 21, 34 -54 Poplar Road, Melbourne, VIC, 3050, Australia.
Kylie RadfordNeuroscience Research Australia, Sydney, Australia.
Sarah RussellCollege of Medicine and Dentistry, James Cook University, Cairns, QLD, Australia.
Leon FlickerWestern Australian Centre for Health and Ageing, Medical School, University of Western Australia, Perth, Australia.
Rachel QuigleyCollege of Medicine and Dentistry, James Cook University, Cairns, QLD, Australia.
Roslyn MalayWestern Australian Centre for Health and Ageing, Medical School, University of Western Australia, Perth, Australia.
Edward StrivensCollege of Medicine and Dentistry, James Cook University, Cairns, QLD, Australia.
Adrienne WithallSchool of Psychology, University of New South Wales, Sydney, Australia.
Louise LavrencicNeuroscience Research Australia, Sydney, Australia.
Brian DraperFalls, Balance and Injury Research Centre, Neuroscience Research Australia, Sydney, Australia.
Kim DelbaereSchool of Population Health, University of New South Wales, Sydney, Australia.
Robert CummingSchool of Public Health, University of Sydney, Sydney, Australia.
Dina LoGiudiceDepartment of Medicine - Royal Melbourne Hospital, The University of Melbourne, Royal Park Campus, Administration Building 21, 34 -54 Poplar Road, Melbourne, VIC, 3050, Australia.

Funding

National Health and Medical Research Council 1137425National Health and Medical Research Council 1150337National Health and Medical Research Council 2006797
6 · The paper itself

Abstract

backgroundRates of dementia for Aboriginal and Torres Strait Islander peoples are three to five times greater compared to non-Indigenous Australians, with earlier age of onset. However, the risk and protective factors that drive these higher rates vary across existing cohort studies, with minimal findings on the role of vascular risk factors beyond stroke. Harmonisation of data across studies may offer greater insights through enhanced diversity and strengthened statistical capabilities. This study aims to combine three landmark cohort studies of Aboriginal and Torres Strait Islander participants to better understand the determinants of cognitive health and dementia. METHODS/

designThree cohort studies - the Kimberley Healthy Adults Project (KHAP, N = 363), Koori Growing Old Well Study (KGOWS, N = 336) and Torres Strait Dementia Prevalence Study (TSDPS, N = 274) - share a similar research methodology with demographic, medical history, psychosocial factors, cognitive tests and consensus clinical diagnoses of cognitive impairment and dementia. Associations between risk and protective factors of interest and the presence of dementia and/or cognitive impairment diagnoses will be evaluated by univariable and multivariable logistic regression in a harmonised cross-sectional cohort of 898 participants. Factors associated with incident dementia and/or cognitive impairment will be assessed in a subset of KHAP (n = 189) and KGOWS participants (n = 165) who were available in longitudinal follow-up, after exclusion of those with baseline dementia or cognitive impairment. Analyses in relation to outcome measure of death or dementia will be conducted to account for the competing risk of death. Logistic regression will be used to evaluate the association between the individual components of the 16-component Kimberley Indigenous Cognitive Assessment (KICA) tool and the presence of dementia and cognitive impairment determined by independent consensus diagnoses. Multivariable binary logistic regression will be used to adjust for the effect of confounding variables. Results will be reported as odds ratios (OR) with 95% confidence intervals (95% CI). DISCUSSION: Greater understanding of risk and protective factors of dementia and cognitive impairment relevant to Aboriginal and Torres Strait Islander peoples may improve approaches across the life course to delay cognitive decline and reduce dementia risk.

Indexed as

Australian Aboriginal and Torres Strait Islander PeoplesCognitive DysfunctionDementiaAdultAgedAustraliaCohort StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedProtective FactorsRisk FactorsAgeingCohort studiesEpidemiologyIndigenous healthPreventative health

Identifiers

PMID38824519
PMCPMC11143581

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.