Evidence map›Paper›PMID 38824486›Full record

ArticleJournal of thrombosis and thrombolysis2024

Effect of Ultrasound on Thrombus debris during Sonothrombolysis in a Microfluidic device.

Xiaobing Zheng, Yunfan Pan, Zhaojian Wang, Shuguang Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of thrombosis and thrombolysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaobing ZhengState Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China. zxb19@mails.tsinghua.edu.cn.ORCID http://orcid.org/0009-0000-3733-7596
Yunfan PanState Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China.
Zhaojian WangPeking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Shuguang ZhangState Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China. shuguang0502@163.com.

Funding

Beijing Natural Science Foundation M22028National Key Research and Development Program of China 2018YFE0114900National Natural Science Foundation of China 52025051,52205208,82170516
6 · The paper itself

Abstract

Microbubble-mediated sonothrombolysis has been proven to be a non-invasive and efficient method for thrombolysis. Nevertheless, there is a potential risk that the thrombus debris generated during the dissolution of the original thrombus are too large and can lead to hazardous emboli. Using a sonothrombolysis microfluidic platform, we investigated the effects of ultrasound power, thrombolytic agent and microbubble concentration on the size of thrombus debris with the example of microbubble-mediated sonothrombolysis of arterial thrombus. Additionally, we studied the effects of ultrasound power on the size and shape of thrombus debris produced by acute and chronic arterial sonothrombolysis. In acute arterial sonothrombolysis, ultrasound power has significant effect on the size of thrombus debris and steadily increases with the increase of ultrasound power. Conversely, in chronic arterial sonothrombolysis, the size of thrombus debris is minimally affected by ultrasound power. Using the sonothrombolysis microfluidic platform, the relationship between ultrasound power and the safety of sonothrombolysis has been illustrated, and the sonothrombolysis microfluidic platform is demonstrated to be a promising tool for further studies on the process of sonothrombolysis.

Indexed as

MicrobubblesThrombosisUltrasonic TherapyFibrinolytic AgentsHumansLab-On-A-Chip DevicesThrombolytic TherapyFibrinolytic AgentsArterial thrombosisMicrofluidic deviceSonothrombolysisThrombus debrisUltrasonic energy

Identifiers

PMID38824486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.