Evidence map›Paper›PMID 38824265›Full record

ArticleMolecular biology reports2024

Molecular characterization, expression and immune functional analysis of cystatin 10 in turbot.

Fan Zhang, Zhixiang Duan, Qiannan Chen, Xuangang Wang, Hengshun Li, Ze Tao, Zhentao Chen, Gan Yu, Haiyang Yu

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Fan ZhangKey Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, 266003, Shandong, China.
Zhixiang DuanKey Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, 266003, Shandong, China.
Qiannan ChenKey Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, 266003, Shandong, China.
Xuangang WangKey Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, 266003, Shandong, China.
Hengshun LiKey Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, 266003, Shandong, China.
Ze TaoKey Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, 266003, Shandong, China.
Zhentao ChenKey Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, 266003, Shandong, China.
Gan YuKey Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, 266003, Shandong, China.
Haiyang YuKey Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, 266003, Shandong, China. yuhaiyang@ouc.edu.cn.

Funding

National Key Research and Development Program of China No. 2022YFD2400400
6 · The paper itself

Abstract

backgroundCystatin is a protease inhibitor that also regulates genes expression linked to inflammation and plays a role in defense and regulation. METHODS AND

resultsCystatin 10 (Smcys10) was cloned from Scophthalmus maximus and encodes a 145 amino acid polypeptide. The results of qRT-PCR showed that Smcys10 exhibited tissue-specific expression patterns, and its expression was significantly higher in the skin than in other tissues. The expression level of Smcys10 was significantly different in the skin, gill, head kidney, spleen and macrophages after Vibrio anguillarum infection, indicating that Smcys10 may play an important role in resistance to V. anguillarum infection. The recombinant Smcys10 protein showed binding and agglutinating activity in a Ca

conclusionsThese results indicated that Smcys10 is involved in the host antibacterial immune response.

Indexed as

CystatinsFish DiseasesFish ProteinsFlatfishesMacrophagesVibrioAnimalsCloning, MolecularGene Expression RegulationNF-kappa BVibrio InfectionsCystatinsFish ProteinsNF-kappa BCystatin 10Immune responseScophthalmus maximusVibrio anguillarum

Identifiers

PMID38824265

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.