Evidence map›Paper›PMID 38824254›Full record

ArticleNeuromolecular medicine2024

p39 Affects Myelin Formation in Cerebral Ischemic Injury.

Danyang Meng, Di Wu, Xiaojing Li, Zhigang Miao

Abstract read
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In one paragraph

Article in Neuromolecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Danyang MengDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Di WuDepartment of Neurology, Nanjing Jinling Hospital, Nanjing, China.
Xiaojing LiSuzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China. lixiaojing_chen@163.com.
Zhigang MiaoDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China. zgmiao@suda.edu.cn.

Funding

the Basic Frontier Innovation Cross Program of Suzhou Medical College YXY2304057
6 · The paper itself

Abstract

Stroke is a significant public health issue, and research has consistently focused on studying the mechanisms of injury and identifying new targets. As a CDK5 activator, p39 plays a crucial role in various diseases. In this article, we will explore the role and mechanism of p39 in cerebral ischemic injury. We measured the level of p39 using western blot and QPCR at various time points following cerebral ischemia-reperfusion (I/R) injury. The results indicated a significant reduction in the level of p39. TTC staining and behavioral results indicate that the knockout of p39 (p39KO) provides neuroprotection in the short-term. Interestingly, the behavioral dysfunction in p39KO mice was exacerbated after the repair phase of I/R. Further study revealed that this deterioration may be due to demyelination induced by elevated p35 levels. In summary, our study offers profound insights into the significance of p39 in both the acute and repair stages of ischemic injury recovery and a theoretical foundation for future therapeutic drug exploration.

Indexed as

Mice, Inbred C57BLMice, KnockoutMyelin SheathReperfusion InjuryAnimalsBrain IschemiaCytoskeletal ProteinsDemyelinating DiseasesInfarction, Middle Cerebral ArteryLipid-Linked ProteinsMaleMicePhosphotransferasesCdk5r1 protein, mouseCdk5r2 protein, mouseCytoskeletal ProteinsLipid-Linked ProteinsPhosphotransferasesIschemicMyelinp35p39

Identifiers

PMID38824254

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.