Is diet related to skin condition? A Mendelian randomization study.

Qinyuan Wang, Zeming Qiu, Long Cheng, Siping Xu, Honggang Li, Jingjing Guo, Xuanfen Zhang

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Article in Archives of dermatological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Qinyuan Wang *Department of Plastic Surgery, The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, China.

Zeming Qiu *The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, China.

Long ChengThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, China.

Siping XuDepartment of Plastic Surgery, The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, China.

Honggang LiDepartment of Plastic Surgery, The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, China.

Jingjing GuoDepartment of Plastic Surgery, The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, China.

Xuanfen ZhangDepartment of Plastic Surgery, The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, China. zhang_xf@lzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Observational studies have revealed associations between various dietary factors and skin conditions. However, the causal relationship between diet and skin condition is still unknown. Data on 17 dietary factors were obtained from the UK Biobank. Data on four skin conditions were derived from the UK Biobank and another large-scale GWAS study. Genetic predictions suggested that the intake of oily fish was associated with a lower risk of skin aging (OR: 0.962, P = 0.036) and skin pigmentation (OR: 0.973, P = 0.033); Tea intake was associated with a lower risk of skin pigmentation (OR: 0.972, P = 0.024); Salad/raw vegetables intake was associated with a lower risk of keratinocyte skin cancer (OR: 0.952, P = 0.007). Coffee intake was associated with increased risk of skin aging (OR: 1.040, P = 0.028); Pork intake was associated with increased risk of skin aging (OR: 1.134, P = 0.020); Beef intake was associated with increased risk of cutaneous melanoma (OR: 1.013, P = 0.016); Champagne plus white wine intake was associated with increased risk of cutaneous melanoma (OR: 1.033, P = 0.004); Bread intake was associated with increased risk of keratinocyte skin cancer (OR: 1.026, P = 0.013). Our study results indicate causal relationships between genetically predicted intake of oily fish, tea, salad/raw vegetables, coffee, pork, beef, champagne plus white wine, and bread and skin conditions.

Indexed as

DietMendelian Randomization AnalysisSkin NeoplasmsCoffeeGenome-Wide Association StudyHumansRisk FactorsSkin AgingSkin PigmentationTeaUnited KingdomCoffeeTeaDietMendelian randomizationScarring and skin fibrosisSkin agingSkin carcinogenesisSkin pigmentation

Identifiers

PMID38824251

DOI10.1007/s00403-024-03103-z

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.