Evidence map›Paper›PMID 38824214›Full record

ArticleMolecular biology reports2024

Formulation of quinoa oil-alginate loaded nanoemulsion and its anticancer efficacy as a therapy for chemically induced breast cancer.

Aida I El Makawy, Dalia M Mabrouk, Faten M Ibrahim, Sekena H Abdel-Aziem, Heba A M Abd El-Kader, Dalia A Youssef, Hafiza A Sharaf, Shaimaa E Mohammed

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aida I El MakawyCell Biology Department, Biotechnology Research Institute, National Research Centre, 33 El Bohouth St., Dokki, Giza, P. O. 12622, Egypt. aelmakawy@yahoo.com.ORCID http://orcid.org/0000-0001-8335-5381
Dalia M MabroukCell Biology Department, Biotechnology Research Institute, National Research Centre, 33 El Bohouth St., Dokki, Giza, P. O. 12622, Egypt.
Faten M IbrahimMedicinal and Aromatic Plants Research Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Bohouth St., Dokki, Giza, P. O. 12622, Egypt.
Sekena H Abdel-AziemCell Biology Department, Biotechnology Research Institute, National Research Centre, 33 El Bohouth St., Dokki, Giza, P. O. 12622, Egypt.
Heba A M Abd El-KaderCell Biology Department, Biotechnology Research Institute, National Research Centre, 33 El Bohouth St., Dokki, Giza, P. O. 12622, Egypt.
Dalia A YoussefPests and plant protection Department, Agricultural and Biology Research Institute, National Research Centre, 33 El Bohouth St., Dokki, Giza, P. O. 12622, Egypt.
Hafiza A SharafPathology Department, Medicine and Clinical Studies Research Institute, National Research Centre, 33 El Bohouth St., Dokki, Giza, P. O. 12622, Egypt.
Shaimaa E MohammedFood Sciences and Nutrition Department, Food Industries and Nutrition Research institute, National Research Centre, 33 El Bohouth St., Dokki, Giza, P. O. 12622, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundQuinoa seeds (Chenopodium quinoa Willd.) have gained interest due to their naturally occurring phytochemicals and antioxidants. They possess potent anticancer properties against human colorectal cancer. METHODS AND

resultsFatty acids in quinoa oil were studied using gas chromatography-mass spectrometry. Rats were used to test the acute oral toxicity of the nanoemulsion loaded with sodium alginate. The DPPH radical scavenging method was employed to assess the nanoemulsion's ability to scavenge free radicals. It was examined the in vivo anticancer potential of quinoa oil nanoemulsion on rats with breast cancer induced by 7, 12-dimethylbenz (a) anthracene (DMBA). DMBA-breast cancer models received daily quinoa oil nanoemulsions for 30 days. The anticancer effect of the nanoemulsion was assessed by measuring ROS, protein carbonyl, gene expression of anti-oncogenes, and histopathological analysis. Supplying quinoa oil nanoemulsion significantly reduced the increase in serum ROS and PC levels induced in breast cancer tissue. The expression levels of antioncogenes in breast cancer tissue were decreased by the quinoa oil nanoemulsion. Nanoemulsions also improved the cellular morphology of breast tumors.

conclusionThe study results indicate that quinoa oil nanoemulsion has anticancer activity against breast cancer, effectively modulating oxidative stress markers, anti-oncogene expressions, and tissue architecture. It can be inferred from the results that quinoa oil nanoemulsion is a chemoprotective medication that may hinder breast cancer progression in rats.

Indexed as

AlginatesBreast NeoplasmsChenopodium quinoaEmulsionsPlant OilsAnimalsAntineoplastic AgentsAntioxidantsFemaleHumansNanoparticlesOxidative StressRatsReactive Oxygen SpeciesSeedsAlginatesAntineoplastic AgentsAntioxidantsEmulsionsPlant OilsReactive Oxygen SpeciesAnti-oncogenesBreast cancerNanoemultionOxidative stress markersTissue structure

Identifiers

PMID38824214

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.