Evidence map›Paper›PMID 38824143›Full record

ArticleCell death & disease2024

A novel doxorubicin/CTLA-4 blocker co-loaded drug delivery system improves efficacy and safety in antitumor therapy.

Wenli Yang, Qinghui Sun, Xiaodian Zhang, Liping Zheng, Xiaomei Yang, Na He, Yanyang Pang, Xi Wang, Zhiheng Lai, Wuping Zheng and 2 more

Abstract read
In one paragraph

Article in Cell death & disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
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  11. Article
  12. Emerging Research and Future Directions on Doxorubicin: A Snapshot.Asian Pacific journal of cancer prevention : APJCP · 2025
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenli Yang *Public Research Center, Hainan Medical University, Haikou, China.
Qinghui Sun *Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiaodian Zhang *Hainan Cancer Medical Center of The First Affiliated Hospital, Hainan Engineering Research Center for Biological Sample Resources of Major Diseases, Hainan Medical University, Haikou, China.
Liping Zheng *Department of Breast Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
Xiaomei Yang *Guangxi Key Laboratory of Nanobody Research/Guangxi Nanobody Engineering Research Center, Guangxi Medical University, Nanning, Guangxi, China.
Na He *School of Tropical Medicine, Hainan MedicalUniversity, Haikou, China.
Yanyang PangSchool of Traditional Chinese Medicine, Hainan Medical University, Haikou, China.
Xi WangDepartment of Anesthesiology, Haikou Third People's Hospital, Haikou, China.
Zhiheng LaiDepartment of Anorectal, Hainan Province Hospital of Traditional Chinese Medicine, Haikou, China.
Wuping ZhengDepartment of Breast and Thyroid Surgery, The Second Affiliated Hospital of Hainan Medical University, Haikou, China. hnzwp2000@163.com.ORCID 0000-0003-0259-0457
Shaoping ZhengDepartment of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. zhengspxx@126.com.ORCID 0009-0005-6608-0060
Wu WangPublic Research Center, Hainan Medical University, Haikou, China. wangwu19880406@sina.com.ORCID 0009-0003-6192-1209

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Doxorubicin's antitumor effectiveness may be constrained with ineffective tumor penetration, systemic adverse effects, as well as drug resistance. The co-loading of immune checkpoint inhibitors and doxorubicin into liposomes can produce synergistic benefits and address problems, including quick drug clearance, toxicity, and low drug penetration efficiency. In our previous study, we modified a nanobody targeting CTLA-4 onto liposomes (LPS-Nb36) to be an extremely potent CTLA-4 signal blocker which improve the CD8

Indexed as

CTLA-4 AntigenDoxorubicinDrug Delivery SystemsLiposomesAnimalsCD8-Positive T-LymphocytesCell Line, TumorFemaleHumansMiceMice, Inbred BALB CMice, Inbred C57BLCTLA-4 AntigenDoxorubicinLiposomes

Identifiers

PMID38824143
PMCPMC11144200

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.