Evidence map›Paper›PMID 38824066›Full record

ReviewTrends in parasitology2024

Arthropod promoters for genetic control of disease vectors.

Jakub Wudarski, Simindokht Aliabadi, Monika Gulia-Nuss

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in parasitology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jakub WudarskiDepartment of Biochemistry and Molecular Biology, University of Nevada, Reno, NV, USA.
Simindokht AliabadiDepartment of Biochemistry and Molecular Biology, University of Nevada, Reno, NV, USA.
Monika Gulia-NussDepartment of Biochemistry and Molecular Biology, University of Nevada, Reno, NV, USA. Electronic address: mgulianuss@unr.edu.

Funding

Germline Transformation of TicksR01AI172943 · NIAID · UNIVERSITY OF NEVADA RENO · PI Monika Gulia-Nuss · 2023 to 2026
$2.7M
Identification of stage-and tissue-specific endogenous tick promotersR21AI176352 · NIAID · UNIVERSITY OF NEVADA RENO · PI GULIA-NUSS, MONIKA · 2023 to 2024
$439k
Development of transgenic protocols for the Lyme disease vector, Ixodes scapularis, for tick and tick-borne disease controlR21AI128393 · NIAID · UNIVERSITY OF NEVADA RENO · PI GULIA-NUSS, MONIKA · 2018 to 2019
$408k
NIAID NIH HHS R01 AI172943NIAID NIH HHS R21 AI128393NIAID NIH HHS R21 AI176352
6 · The paper itself

Abstract

Vector-borne diseases (VBDs) impose devastating effects on human health and a heavy financial burden. Malaria, Lyme disease, and dengue fever are just a few examples of VBDs that cause severe illnesses. The current strategies to control VBDs consist mainly of environmental modification and chemical use, and to a small extent, genetic approaches. The genetic approaches, including transgenesis/genome modification and gene-drive technologies, provide the basis for developing new tools for VBD prevention by suppressing vector populations or reducing their capacity to transmit pathogens. The regulatory elements such as promoters are required for a robust sex-, tissue-, and stage-specific transgene expression. As discussed in this review, information on the regulatory elements is available for mosquito vectors but is scant for other vectors.

Indexed as

Promoter Regions, GeneticVector Borne DiseasesAnimalsArthropod VectorsHumansarthropodgenetic engineeringgenetic expressionpromotertransgenesisvector-borne diseases

Identifiers

PMID38824066
PMCPMC11223965

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.