ArticleHeart rhythm2024
Prevalence and predictors of mitral annular disjunction and ventricular ectopy in mitral valve prolapse.
Article in Heart rhythm, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mitral annular disjunction and high-risk profiles: a conceptual approach to risk stratification and surgical implications.General thoracic and cardiovascular surgery · 2026Pooled it
- Mitral Annular Disjunction: Form, Force, and Function.JACC. Case reports · 2026Article
- Arrhythmic Mitral Valve Prolapse as a Regional Stretch-Induced Cardiomyopathy with Fibro-Inflammatory Signature: A Conceptual Review.Journal of cardiovascular development and disease · 2026Review
- Explainable machine learning and unsupervised anatomical phenotyping of mitral valve prolapse in patients with severe mitral regurgitation.BMC cardiovascular disorders · 2026Article
- Ventricular arrhythmias in patients undergoing degenerative mitral repair: Prevalence and impact on survival.The Journal of thoracic and cardiovascular surgery · 2026Article
- Ventricular arrhythmic burden before and after mitral valve repair in mitral valve prolapse: the role of mitral annular disjunction.Frontiers in cardiovascular medicine · 2026Article
- Does Preliminary Chest Shape Assessment Improve the Prognostic Risk Stratification of Individuals with Mitral Annular Disjunction? A Case Report and Narrative Review.Journal of clinical medicine · 2025Article
- The Prevalence, Pathophysiological Role and Determinants of Mitral Annular Disjunction Among Patients with Mitral Valve Prolapse: A Systematic Review.Journal of clinical medicine · 2025Review
- Left ventricular hypertrophy and ventricular ectopy in mitral valve prolapse.International journal of cardiology · 2025Article
- Arrhythmogenic mitral valve prolapse and mitral annular disjunction: a literature review and case-based perspective.Frontiers in cardiovascular medicine · 2025Review
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7 authors.
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Abstract
backgroundMitral annular disjunction (MAD) is associated with ventricular arrhythmia in mitral valve prolapse (MVP). The proportional risk from MAD and other predictors of ventricular arrhythmia in MVP has not been well characterized.
objectiveThis study aimed to identify predictors of complex or frequent ventricular ectopy (cfVE) in MVP and to quantify risk of cfVE and mortality in MVP with MAD.
methodsWe studied 632 adult patients with MVP on transthoracic echocardiography at the University of North Carolina Medical Center from 2016 to 2019 (median age, 64 [interquartile range, 52-74] years; 52.7% female; 16.3% African American). Resting and ambulatory electrocardiograms were used to identify cfVE.
resultsMAD was present in 94 (14.9%) patients. Independent associations of MAD were bileaflet prolapse (odds ratio [95% CI], 4.25 [2.47-7.33]; P < .0001), myxomatous valve (2.17 [1.27-3.71]; P = .005), absence of hypertension (2.00 [1.21-3.32]; P = .007), electrocardiogram inferior or lateral lead T-wave inversion (2.07 [1.23-3.48]; P = .006), and female sex (1.99 [1.21-3.25]; P = .006). cfVE was frequent with MAD (39 [41.5%] vs 93 [17.3%] without; P < .0001). Independent cfVE predictors were MAD (hazard ratio [95% CI], 2.23 [1.47-3.36]; P = .0001), bileaflet prolapse (1.86 [1.25-2.76]; P = .002), heart failure (1.79 [1.16-2.77]; P = .009), lower left ventricular ejection fraction (0.14 [0.03-0.61]; P = .009), coronary artery disease (1.60 [1.05-2.43]; P = .03), and inferior or lateral lead T-wave inversion (1.51 [1.03-2.22]; P = .03). After a median of 40 (33-48) months, there was increased mortality with MAD (P = .04).
conclusionMAD in MVP is associated with bileaflet or myxomatous MVP, absence of hypertension, T-wave inversion, and female sex. There is increased cfVE and mortality with MAD, highlighting the need for closer follow-up of these patients.
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