Evidence map›Paper›PMID 38823641›Full record

ArticleThe Journal of biological chemistry2024

Distinct roles of the major binding residues in the cation-binding pocket of the melibiose transporter MelB.

Parameswaran Hariharan, Amirhossein Bakhtiiari, Ruibin Liang, Lan Guan

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Structure and allostery in major facilitator superfamily symport mechanisms.Acta crystallographica. Section D, Structural biology · 2026
    Article
  2. Article
  3. Allosteric effects of the coupling cation in melibiose transporter MelB.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Parameswaran HariharanDepartment of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Amirhossein BakhtiiariDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, USA.
Ruibin LiangDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, USA. Electronic address: rliang@ttu.edu.
Lan GuanDepartment of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA. Electronic address: Lan.Guan@ttuhsc.edu.

Funding

Understanding electronically non-adiabatic reactions in biomolecules with multiscale simulationsR35GM150780 · NIGMS · TEXAS TECH UNIVERSITY · PI Ruibin Liang · 2023 to 2026
$1.4M
Integrated approaches to symport mechanisms of membrane transportersR01GM122759 · NIGMS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI GUAN, LAN · 2018 to 2021
$1.4M
NIGMS NIH HHS R01 GM122759NIGMS NIH HHS R35 GM150780
6 · The paper itself

Abstract

Salmonella enterica serovar Typhimurium melibiose permease (MelB

Indexed as

SodiumSymportersBacterial ProteinsBinding SitesCationsCrystallography, X-RayMelibioseProtein ConformationSalmonella typhimuriumBacterial ProteinsCationsMelibiosemelibiose permeaseSodiumSymportersbioenergeticscation selectivityexternal pHITCmelibiose permeasePEFprotonationsymport

Identifiers

PMID38823641
PMCPMC11259710

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.