Evidence map›Paper›PMID 38823076›Full record

ArticleEpilepsy & behavior : E&B2024

Assessing the feasibility of digital keypress statistics to detect seizures and capture cognitive impairment in patients with epilepsy: A pilot study.

Gabriella Brinkmann, Andrea Duque-Lopez, Jie Cui, Louis Faust, Eva C Alden, Gregory Worrell, Benjamin H Brinkmann

Abstract read
In one paragraph

Article in Epilepsy & behavior : E&B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Gabriella BrinkmannBrain Neurology and Engineering Lab, Department of Neurology, Mayo Foundation, Rochester MN 55905, United States.
Andrea Duque-LopezBrain Neurology and Engineering Lab, Department of Neurology, Mayo Foundation, Rochester MN 55905, United States.
Jie CuiBrain Neurology and Engineering Lab, Department of Neurology, Mayo Foundation, Rochester MN 55905, United States.
Louis FaustKern Center for Healthcare Delivery, Mayo Foundation, Rochester MN 55905, United States.
Eva C AldenDepartment of Psychiatry and Psychology, Mayo Foundation, Rochester MN 55905, United States.
Gregory WorrellBrain Neurology and Engineering Lab, Department of Neurology, Mayo Foundation, Rochester MN 55905, United States.
Benjamin H BrinkmannBrain Neurology and Engineering Lab, Department of Neurology, Mayo Foundation, Rochester MN 55905, United States. Electronic address: Brinkmann.benjamin@mayo.edu.

Funding

Optimizing Pharmacotherapy with Noninvasive Wearable Sensors and Subscalp EEGUH3NS123066 · NINDS · MAYO CLINIC ROCHESTER · PI Benjamin H Brinkmann, Gregory A Worrell · 2025 to 2026
$1.4M
Optimizing Pharmacotherapy with Noninvasive Wearable Sensors and Subscalp EEGUG3NS123066 · NINDS · MAYO CLINIC ROCHESTER · PI BRINKMANN, BENJAMIN H, WORRELL, GREGORY A · 2022 to 2024
$1.2M
NINDS NIH HHS UG3 NS123066NINDS NIH HHS UH3 NS123066
6 · The paper itself

Abstract

backgroundEfficient, non-invasive monitoring may provide a more accurate and comprehensive understanding of seizure frequency and the development of some comorbidities in people with epilepsy. Novel keyboard technology measuring digital keypress statistics has demonstrated its practical value for neurodegenerative diseases including Parkinson's Disease and Dementia. Smartphones integrated into daily life may serve as a low-burden longitudinal monitoring system for patients with epilepsy.

objectiveThis study aimed to assess the feasibility of keyboard statistics as an objective measure of seizure frequency for patients with epilepsy, in addition to tracking differences between cognitively normal and cognitively impaired patients.

methodsSix adult patients admitted to the Epilepsy Monitoring Unit (EMU) at Mayo Clinic in Rochester, Minnesota were studied. The keyboard was installed on the patient's smartphone. In the EMU, typing statistics were correlated to electroencephalogram (EEG) confirmed seizures. After discharge, participants continued using their keyboards and kept a seizure log. We also analyzed the key press/release times and usage of participants' keyboards for adherence.

resultsKeyboard sessions during and after seizures assessed for key press/release differences versus baseline showed no statistically significant difference (p = 0.44). Using one-way ANOVA, cognitive impairment's potential impact on keyboard statistics was explored in patients who had neuropsychological testing (N = 3). Significant differences were found between patients with and without cognitive impairment (p < 0.001). No significant difference was noted between patients with mild intellectual disability and normal cognitive function (p = 0.55).

Indexed as

Cognitive DysfunctionElectroencephalographyEpilepsyFeasibility StudiesSeizuresAdultAgedFemaleHumansMaleMiddle AgedNeuropsychological TestsPilot ProjectsSmartphoneCognitive impairmentComorbiditiesDigital healthNon-invasive monitoring

Identifiers

PMID38823076
PMCPMC11286342

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.