ArticleActa veterinaria Scandinavica2024
Effects of vatinoxan in rats sedated with a combination of medetomidine, midazolam and fentanyl.
Article in Acta veterinaria Scandinavica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Microcirculatory impact of vatinoxan and fentanyl in male Wistar rats sedated with medetomidine and midazolam.BMC veterinary research · 2026Article
- Effects of vatinoxan and fentanyl on blood glucose concentrations and diuresis in male Wistar rats sedated with medetomidine and midazolam.BMC veterinary research · 2026Article
- Overdose Effects of Medetomidine and Fentanyl in Rats: Reflex, Vital and Analgesic Parameters as Predictive Markers.Veterinary medicine (Auckland, N.Z.) · 2026Article
- The Impact of Vatinoxan on the Concentrations of Medetomidine, Midazolam, and Fentanyl in Central Nervous System After Subcutaneous Co-Administration in Rats.Journal of veterinary pharmacology and therapeutics · 2025Article
- Dual-route administration of balanced anesthesia using medetomidine, midazolam, and butorphanol provides both suitable anesthetic depth and reduced tissue injury in rabbits.Experimental animals · 2025Article
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Authors and funding
3 authors.
Funding
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Abstract
backgroundAlpha2-adrenoceptor agonists (α
resultsOnset of sedation and loss of righting reflex occurred significantly faster with vatinoxan [5.35 ± 1.08 (mean ± SD) versus 12.97 ± 6.18 min and 6.53 ± 2.18 versus 14.47 ± 7.28 min, respectively]. No significant differences were detected in heart and respiratory rates and arterial oxygen saturation between treatments. Blood glucose concentration (18.3 ± 3.6 versus 11.8 ± 1.2 mmol/L) and spontaneous urinary voiding [35.9 (15.1-41.6), range (median) versus 0.9 (0-8.0) mL /kg/min] were significantly higher without vatinoxan.
conclusionsAcceleration of induction of sedation, alleviation of hyperglycaemia and prevention of profuse diuresis by vatinoxan may be beneficial when sedating rats for clinical and experimental purposes with subcutaneous medetomidine, midazolam and fentanyl.
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