ArticleCardiovascular diabetology2024
Triglyceride-glucose index is associated with myocardial ischemia and poor prognosis in patients with ischemia and no obstructive coronary artery disease.
Article in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Estimated glucose disposal rate (eGDR) predicts rehospitalization & death in acute decompensated heart failure in the elderly.Heart and vessels · 2026Article
- Joint effects of triglyceride-glucose-BMI and stress hyperglycemia ratio on all-cause mortality in trauma surgical intensive care patients: a multicenter cohort study.Lipids in health and disease · 2026Article
- The Role of the Triglyceride-Glucose Index and Other Prognostic Factors in Predicting Coronary Slow Flow.Journal of cardiovascular development and disease · 2026Article
- TyG index predicts adverse cardiovascular outcomes in patients with multimorbidity of hypertension and obstructive coronary artery disease: a cohort study.Frontiers in cardiovascular medicine · 2026Article
- Article
- Comparison of TyG and modified TyG indices in predicting coronary slow flow phenomenon.BMC cardiovascular disorders · 2025Article
- The association between novel metabolic parameters and all-cause/cardiovascular mortality in patients with metabolic syndrome is modified by age.Cardiovascular diabetology · 2025Article
- The additional impact of metabolic syndrome on left ventricular deformation and myocardial energetic efficiency impairment in ischemia with nonobstructive coronary arteries patients.Cardiovascular diabetology · 2025Article
- Hyperglycemia, diabetes, and coronary microvascular dysfunction in INOCA.Frontiers in endocrinology · 2025Article
- The metabolic score for insulin resistance index is associated with myocardial ischemia, with non-alcoholic fatty liver disease serving as an important bridge.Frontiers in endocrinology · 2025Article
- Predictive value of the triglyceride-glucose index for short- and long-term all-cause mortality in patients with critical coronary artery disease: a cohort study from the MIMIC-IV database.Lipids in health and disease · 2024Article
- Endothelial microRNAs in INOCA patients with diabetes mellitus.Cardiovascular diabetology · 2024Article
- Associations between non-insulin-based insulin resistance indices and diabetic nephropathy in patients with diabetes mellitus in US adults: a cross-sectional study of NHANES 1999-2018.Frontiers in endocrinology · 2024Article
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14 authors.
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Abstract
backgroundIschemia and no obstructive coronary artery disease (INOCA) is increasingly recognized and associated with poor outcomes. The triglyceride-glucose (TyG) index is a reliable alternative measure of insulin resistance significantly linked to cardiovascular disease and adverse prognosis. We investigated the association between the TyG index and myocardial ischemia and the prognosis in INOCA patients.
methodsINOCA patients who underwent both coronary angiography and myocardial perfusion imaging (MPI) were included consecutively. All participants were divided into three groups according to TyG tertiles (T1, T2, and T3). Abnormal MPI for myocardial ischemia in individual coronary territories was defined as summed stress score (SSS) ≥ 4 and summed difference score (SDS) ≥ 2. SSS refers to the sum of all defects in the stress images, and SDS is the difference of the sum of all defects between the rest images and stress images. All patients were followed up for major adverse cardiac events (MACE).
resultsAmong 332 INOCA patients, 113 (34.0%) had abnormal MPI. Patients with higher TyG index had a higher rate of abnormal MPI (25.5% vs. 32.4% vs. 44.1%; p = 0.012). Multivariate logistic analysis showed that a high TyG index was significantly correlated with abnormal MPI in INOCA patients (OR, 1.901; 95% CI, 1.045-3.458; P = 0.035). During the median 35 months of follow-up, 83 (25%) MACE were recorded, and a higher incidence of MACE was observed in the T3 group (T3 vs. T2 vs. T1: 36.9% vs. 21.6% vs. 16.4%, respectively; p = 0.001). In multivariate Cox regression analysis, the T3 group was significantly associated with the risk of MACE compared to the T1 group (HR, 2.338; 95% CI 1.253-4.364, P = 0.008).
conclusionThis study indicates for the first time that the TyG index is significantly associated with myocardial ischemia and poor prognosis among INOCA patients.
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