Evidence map›Paper›PMID 38822363›Full record

ArticleJournal of experimental & clinical cancer research : CR2024

METTL1-mediated tRNA m

Dan Du, Mingxia Zhou, Chenxi Ju, Jie Yin, Chang Wang, Xinyu Xu, Yunqing Yang, Yun Li, Le Cui, Zhengyang Wang and 4 more

Abstract read
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Adenosine 5'-Carboxamide-Based Inhibitors of METTL1.ACS medicinal chemistry letters · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. WDR5-H3K4me3 Epigenetic Axis Promotes TRMT6-Dependent tRNA MAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Review
  10. METTL1-Mediated NMedComm · 2026
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. [Targeting chimera technology: A new tool for undruggable in breast cancer].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  17. Article
  18. Deciphering the secret codes in NClinical and translational medicine · 2025
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dan Du *Department of Medical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Mingxia Zhou *Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Chenxi Ju *Department of Medical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Jie YinDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Chang WangDepartment of Medical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Xinyu XuDepartment of Medical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yunqing YangDepartment of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yun LiDepartment of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Le CuiDepartment of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Zhengyang WangDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yuqing LeiDepartment of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450008, China.
Hongle LiDepartment of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450008, China. llhl73@163.com.
Fucheng HeDepartment of Medical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. hefucheng@zzu.edu.cn.
Jing HeDepartment of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. hejing921@zzu.edu.cn.ORCID http://orcid.org/0000-0001-5306-4321

Funding

National Natural Science Foundation of China 82203332National Natural Science Foundation of China 82272417National Natural Science Foundation of China 82300606
6 · The paper itself

Abstract

backgroundRNA modifications of transfer RNAs (tRNAs) are critical for tRNA function. Growing evidence has revealed that tRNA modifications are related to various disease processes, including malignant tumors. However, the biological functions of methyltransferase-like 1 (METTL1)-regulated m

methodsThe biological role of METTL1 in BC progression were examined by cellular loss- and gain-of-function tests and xenograft models both in vitro and in vivo. To investigate the change of m

resultsThe tRNA m

conclusionOur study uncovered the crucial tumor-suppressive role of METTL1-mediated tRNA m

Indexed as

Breast NeoplasmsMethyltransferasesRNA, TransferAnimalsCarcinogenesisCell Cycle CheckpointsCell Line, TumorCell ProliferationFemaleHumansMethylationMiceMice, NudeProtein BiosynthesisXenograft Model Antitumor AssaysMethyltransferasesMETTL1 protein, humanRNA, TransferBreast cancerCDK4/6Cell cycleGADD45AMETTL1

Identifiers

PMID38822363
PMCPMC11140866

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.