Evidence map›Paper›PMID 38822340›Full record

ArticleBMC ophthalmology2024

Genetic variations of IL10 and IL6R genes in acute anterior uveitis in Han Chinese.

Lin Li, Fuzhen Li, Jiankang Shan, Kunpeng Xie, Pengyi Zhou, Haiyan Zhu, Xuemin Jin, Liping Du, Peizeng Yang

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Article in BMC ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Lin Li *Department of Ophthalmology, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Zhengzhou, Henan, P.R. China.
Fuzhen Li *Department of Ophthalmology, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Zhengzhou, Henan, P.R. China.
Jiankang ShanDepartment of Ophthalmology, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Zhengzhou, Henan, P.R. China.
Kunpeng XieDepartment of Ophthalmology, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Zhengzhou, Henan, P.R. China.
Pengyi ZhouDepartment of Ophthalmology, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Zhengzhou, Henan, P.R. China.
Haiyan ZhuDepartment of Ophthalmology, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Zhengzhou, Henan, P.R. China.
Xuemin JinDepartment of Ophthalmology, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Zhengzhou, Henan, P.R. China.
Liping DuDepartment of Ophthalmology, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Zhengzhou, Henan, P.R. China. dulplab@live.cn.
Peizeng YangDepartment of Ophthalmology, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Zhengzhou, Henan, P.R. China. peizengycmu@126.com.

Funding

Major Program of Medical Scientific and Technological of Henan Province (XXX), Medical Scientific and Technological Project of Henan Province SBGJ2020003031Medical Science and Technology Project of Health Commission of Henan Province YXKC2020026National Natural Science Foundation of China 81970792National Natural Science Foundation of China 82101108National Natural Science Foundation of China 82171040National Natural Science Foundation of China 82301271
6 · The paper itself

Abstract

backgroundSeveral autoimmune disorders have been linked to polymorphisms in IL10 and IL6R genes. This research aimed to study whether single nucleotide polymorphisms (SNPs) in the genes of IL10 and IL6R were associated with acute anterior uveitis (AAU) in Han Chinese.

methodsGenotyping was carried out by the iPLEX Gold Genotyping Assay. Our study comprised 420 patients with AAU and 918 healthy subjects from Han Chinese. Using the chi-square (χ2) test, alleles and genotypes were analyzed between AAU subjects and healthy controls.

resultsAll ten SNPs were successfully genotyped and four SNPs (IL10/rs1800871, IL10/rs3021094, IL10/rs2222202, IL6R/rs4845618) exhibited weak associations with AAU, as indicated by their P

conclusionOur findings suggested that polymorphisms of the tested ten SNPs on the IL10 and IL6R genes did not show any association with the risk of developing AAU among the Han Chinese population.

Indexed as

East Asian PeopleGenetic Predisposition to DiseaseInterleukin-10Receptors, Interleukin-6Uveitis, AnteriorAcute DiseaseAdultAgedAllelesCase-Control StudiesChinaFemaleGene FrequencyGenotypeHaplotypesHumansIL10 protein, humanIL6R protein, humanInterleukin-10Receptors, Interleukin-6Acute anterior uveitisGenetic variationIL10IL6 receptor

Identifiers

PMID38822340
PMCPMC11140953

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