SynthesisBMC public health2024
Update on the practice of premarital screening for sickle cell traits in Africa: a systematic review and meta-analysis.
Synthesis in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Genetic disorders and congenital anomalies in Nigeria: a scoping review.Journal of community genetics · 2026Review
- Genetic blood disorder status awareness and factors influencing willingness or reluctance to undergo premarital screening among young adults in Ahafo Region, Ghana: a cross-sectional survey.Journal of health, population, and nutrition · 2026Article
- Sickle cell anemia and social justice: a pathway to equitable healthcare in Uganda.Annals of medicine and surgery (2012) · 2025Review
- Low uptake and poor knowledge of preconception sickle cell trait screening among pregnant women in Bushenyi District, southwestern Uganda: Implications for sustainable development goals.Preventive medicine reports · 2025Article
- Public-private partnerships in tackling sickle cell disease in Uganda: a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Strategies for reducing child mortality due to sickle cell disease in Uganda: a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Determinants of marital decision despite sickle cell status awareness: a mixed method study.BMC public health · 2025Article
- Managing emotional and physical stress in sickle cell anemia: a review of effective strategies and approaches.Annals of medicine and surgery (2012) · 2025Review
- Hypoxia, Inflammation, and Cytokine Crosstalk in Sickle Cell Disease: From Mechanisms to Modulation- A Narrative Review.Pediatric health, medicine and therapeutics · 2025Review
- Evolving Landscape of Sickle Cell Anemia Management in Africa: A Critical Review.Tropical medicine and infectious disease · 2024Review
- Potassium dynamics in sickle cell anemia: clinical implications and pathophysiological insights.Annals of medicine and surgery (2012) · 2024Review
- Review
- Telomere Dynamics in Sickle Cell Anemia: Unraveling Molecular Aging and Disease Progression.Journal of blood medicine · 2024Review
- Knowledge and Attitudes of Secondary Schools students Towards Premarital Screening and Counseling in Taiz, Yemen.Journal of multidisciplinary healthcare · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundScreening for sickle cell traits before marriage or producing children is one of the outstanding preventive measures for sickle cell disease (SCD).The disease is a collection of inherited blood disorders that impact millions globally, with a predominant 75% occurrence in the sub-Saharan region. With increasing burden of SCD on the continent amidst a cost effective prevention method, no study has systematically reviewed or presented meta-analytic uptake or practice of premarital sickle cell trait screening.
methodsThis review systematically explored the uptake or practice of premarital genotype screening in Africa. We searched PubMed and Scopus databases for African studies on premarital screening for sickle cell traits.
resultsOur results indicate that the pooled uptake of premarital sickle cell trait screening in Africa is 47.82% (95% CI: [46.53-49.11]; I
conclusionWith over 75% of the global burden of sickle cell disease domiciled in Africa, the continent cannot overlook the cost of hemoglobinopathies. The uptake of sickle cell traits screening is suboptimal across the continent. To achieve the mandate of sustainable development goal number (3); to end preventable deaths of newborns and children under 5 years of age by 2030, there is need to intensify campaigns on premarital genetic screening through education and other health promotion tools.
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