Observational studyBMC ophthalmology2024
Corneal densitometry in Chinese adults with healthy corneas: associations with sex, age, ocular metrics, and optical characteristics.
Observational study in BMC ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Determinants of posterior corneal optical densitometry and their relationship with endothelial morphology.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Evaluation of stability and visual quality in Chinese myopic eyes 2 years following FS-LASIK combined with prophylactic corneal crosslinking.BMC ophthalmology · 2026Article
- Corneal optical densitometry in transparent corneas and its correlations with corneal higher-order aberrations.BMC ophthalmology · 2026Article
- One-year effects of orthokeratology lens wear on objective visual quality and corneal densitometry in adolescents with myopia.PloS one · 2026Article
- Corneal optical densitometry and anterior segment parameters in healthy upper Egyptian population: a prospective observational cross-sectional study.BMC ophthalmology · 2025Observational
- Evaluation of corneal densitometry using Pentacam in patients with type 2 diabetes mellitus: a controlled cross-sectional study.BMC ophthalmology · 2025Article
- The effects of fixation stability, corneal density, and epithelial hyperplasia on the efficacy of astigmatism correction by transepithelial photorefractive keratectomy.Eye and vision (London, England) · 2025Article
- Characterization of Directional Reflectance in Corneal Tissue: A Comprehensive Optical Coherence Tomography Analysis.Translational vision science & technology · 2025Article
- Corneal light scattering and anterior segment findings in rheumatoid arthritis patients: a prospective study on disease monitoring.International journal of ophthalmology · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundStandardized corneal densitometry (CD) values in large samples of healthy Chinese individuals are scarce. Therefore, we aimed to determine the standard CD values using a Scheimpflug camera in healthy corneas, investigate the correlations of sex, age, and ocular parameters with corneal density, and explore the impact of corneal density on the forward scattering and optical quality of the eye.
methodsThis retrospective observational study involved 990 healthy Chinese individuals, including 494 males and 496 females (mean age: 23.88 ± 6.90 years). The CD values at various depths and radial areas of 0-12 mm were measured using a Scheimpflug camera. Densitometric measurements were expressed in standardized grayscale units (GSU). The optical scatter index (OSI), modulation transfer function cutoff values (MTF
resultsThe average CD within a 12 mm diameter area was 16.26 ± 1.35 GSU. The highest and lowest optical densities at different depths were observed in the anterior (21.41 ± 2.16 GSU) and posterior (12.00 ± 1.01 GSU) layers, respectively (P < 0.001). Similarly, the maximum and minimum optical densities at different radial areas were observed in the 10-12 mm (14.09 ± 0.93 GSU) and 2-6 mm (25.93 ± 4.77 GSU) circles, respectively (P < 0.001). There was no significant difference in the average CD within a 12 mm diameter area between males and females (P > 0.05). However, upon adjusting for age, central corneal thickness (CCT), corneal curvature, white-to-white (WTW) corneal diameter, and axial length, females exhibited a greater average CD within the 12 mm diameter and in the 6-10 mm and 10-12 mm circles than males. Age-related changes in CD were evident, except in the 2-6 mm circle. CCT, corneal curvature, WTW corneal diameter, and partial depth correlated with CD in the radial area, and CD in different areas correlated with the OSI, MTF
conclusionsThis study provides the normative CD measurement data of Chinese adults with healthy corneas, emphasizing the significance of sex, age, CCT, corneal curvature, and WTW corneal diameter in CD evaluation. Notably, elevated CD can lead to increased forward scattering within the eye, thereby affecting the optical quality.
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