Evidence map›Paper›PMID 38822218›Full record

ArticleBehavior genetics2024

Prospective Effects of Self-Rated Health on Dementia Risk in Two Twin Studies of Aging.

Matthew J D Pilgrim, Christopher R Beam, Marianne Nygaard, Deborah Finkel

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavior genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew J D PilgrimDepartment of Psychology, University of Southern California, Los Angeles, USA. mpilgrim@usc.edu.ORCID 0000-0003-1467-7154
Christopher R BeamDepartment of Psychology, University of Southern California, Los Angeles, USA.ORCID 0000-0001-6827-409X
Marianne NygaardThe Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID 0000-0003-0703-2665
Deborah FinkelCenter for Economic and Social Research, University of Southern California, Los Angeles, USA.ORCID 0000-0003-2346-2470

Funding

TRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI YASHIN, ANATOLIY I · 1990 to 2008
$17.5M
Past, Present, and Future Risk of Cognitive Decline and Cognitive Impairment in the Louisville Twin StudyR01AG063949 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christopher Ryan Beam, DEBORAH WINDERS DAVIS · 2019 to 2026
$7.8M
Sex differences in the relationship between APOE and AD: Role of sexual differentiationRF1AG058068 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET, LADU, MARY JO · 2017 to 2017
$3.8M
Clarifying risk and protective factors for dementia with the Interplay of Genes and Environment in Multiple Studies (IGEMS) consortiumR01AG060470 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET, PEDERSEN, NANCY L · 2018 to 2022
$3.6M
SES health gradients in late life: testing models of gene-environment interplay in an international twin consortiumR01AG059329 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINCH, BRIAN K., GATZ, MARGARET · 2018 to 2022
$2.9M
Alzheimer's Association AARF-17-505302NIA NIH HHS P01 AG008761NIA NIH HHS R01 AG059329NIA NIH HHS R01 AG060470NIA NIH HHS R01AG060470NIA NIH HHS R01 AG063949NIA NIH HHS RF1 AG058068
6 · The paper itself

Abstract

Subjective health ratings are associated with dementia risk such that those who rate their health more poorly have increased risk for dementia. The genetic and environmental mechanisms underlying this association are unclear, as prior research cannot rule out whether the association is due to genetic confounds. The current study addresses this gap in two samples of twins, one from Sweden (N = 548) and one from Denmark (N = 4,373). Using genetically-informed, bivariate regression models, we assessed whether additive genetic effects explained the association between subjective health and dementia risk as indexed by a latent variable proxy measure. Age at intake, sex, education, depressive symptomatology, and follow-up time between subjective health and dementia risk assessments were included as covariates. Results indicate that genetic variance and other sources of confounding accounted for the majority of the effect of subjective health ratings on dementia risk. After adjusting for genetic confounding and other covariates, a small correlation was observed between subjective health and latent dementia risk in the Danish sample (r

Indexed as

AgingDementiaAgedAged, 80 and overDenmarkFemaleHealth StatusHumansMaleMiddle AgedProspective StudiesRisk FactorsSelf ReportSwedenTwins, DizygoticTwins, MonozygoticDementia riskGenetic riskSelf-rated healthSubjective healthTwins

Identifiers

PMID38822218
PMCPMC11196327

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.